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Compound Detail

CHEMBL1084078

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CC1(C)Cc2c([nH]c3ccccc23)C2(N1)C(=O)Nc1ccc(Cl)cc12

Basic Information

ChEMBL ID CHEMBL1084078
Phase Preclinical
Structure Type MOL
InChI Key PSGDCHWXQZRSHI-UHFFFAOYSA-N
1
Targets
5
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names

Molecular Properties

351.8
MW (Da)
3.94
ALogP
2
HBA
3
HBD
56.9
PSA (Ų)
0.57
QED
0
Ro5 Violations
0
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C20H18ClN3O
MW 351.84
Aromatic Rings 3
Heavy Atoms 25
NP-Likeness -0.17

Activity Summary

IC50 5 meas. best 8.57

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Plasmodium falciparum
CHEMBL364
IC50 8.57 6.578 2.7 5

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
34058709 10.1016/j.ejmech.2021.113536 Plasmodium falciparum 3
20568778 10.1021/jm100410f Plasmodium falciparum 2

Data from ChEMBL 36 via Core Engine