Assay Detail

CHEMBL1120022

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Functional

Cytotoxicity against human HUPT4 cells after 96 hrs by MTT assay

ChEMBL ↗

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Target

HuP-T4 (CHEMBL1075478) ↗

Open DB target context

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HuP-T4 (CHEMBL1075478) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target HuP-T4

CHEMBL1075478

Anchored from Assay target.

Protein identity HuP-T4

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	HuP-T4
Confidence	1 — Organism
Curated By	Autocuration

Target

HuP-T4 (CHEMBL1075478) ↗

Type	CELL-LINE
Organism	Homo sapiens

Publication

Discovery of N-phenyl-4-(thiazol-5-yl)pyrimidin-2-amine aurora kinase inhibitors.

Wang S, Midgley CA, Scaërou F, Grabarek JB, Griffiths G, Jackson W, Kontopidis G, McClue SJ, McInnes C, Meades C, Mezna M, Plater A, Stuart I, Thomas MP, Wood G, Clarke RG, Blake DG, Zheleva DI, Lane DP, Jackson RC, Glover DM, Fischer PM.
J Med Chem (2010) 53 : 4367 -4378
PubMed 20462263 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	2	6.46	6.81

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL46817	—	—	1	6.81
CHEMBL482967	CYC-116	1.0	1	6.11

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL46817	—	IC50	=	156.0	nM	6.81
CHEMBL482967	CYC-116	IC50	=	775.0	nM	6.11