Assay Detail

CHEMBL1120023

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Functional

Cytotoxicity against human Saos2 cells after 96 hrs by MTT assay

ChEMBL ↗

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Target

SAOS-2 (CHEMBL614894) ↗

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Primary target SAOS-2

CHEMBL614894

Anchored from Assay target.

Protein identity SAOS-2

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	SAOS-2
Confidence	1 — Organism
Curated By	Autocuration

Target

SAOS-2 (CHEMBL614894) ↗

Type	CELL-LINE
Organism	Homo sapiens

Publication

Discovery of N-phenyl-4-(thiazol-5-yl)pyrimidin-2-amine aurora kinase inhibitors.

Wang S, Midgley CA, Scaërou F, Grabarek JB, Griffiths G, Jackson W, Kontopidis G, McClue SJ, McInnes C, Meades C, Mezna M, Plater A, Stuart I, Thomas MP, Wood G, Clarke RG, Blake DG, Zheleva DI, Lane DP, Jackson RC, Glover DM, Fischer PM.
J Med Chem (2010) 53 : 4367 -4378
PubMed 20462263 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	2	6.73	6.96

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL482967	CYC-116	1.0	1	6.96
CHEMBL46817	—	—	1	6.50

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL482967	CYC-116	IC50	=	110.0	nM	6.96
CHEMBL46817	—	IC50	=	320.0	nM	6.50