Assay Detail
Binding
CHEMBL1120075
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of 8-anilino-1-naphthalene-sulfonic acid from human His-FABP4 expressed in Escherichia coli BL21 (DE3) cells after 3 mins relative to linoleic acid
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | BL21-DE3 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Fatty acid-binding protein, adipocyte (CHEMBL2083) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of highly selective inhibitors of human fatty acid binding protein 4 (FABP4) by virtual screening.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.65 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1085570 | — | — | 1 | 6.00 |
| CHEMBL267476 | LINOLEIC ACID | 2.0 | 1 | 6.00 |
| CHEMBL1085571 | — | — | 1 | 5.51 |
| CHEMBL1085797 | — | — | 1 | 5.39 |
| CHEMBL1086224 | — | — | 1 | 5.36 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1085570 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL267476 | LINOLEIC ACID | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL1085571 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL1085797 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL1086224 | — | IC50 | = | 4400.0 | nM | 5.36 |