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Target Snapshot

CHEMBL2083 Target Snapshot

Fatty acid-binding protein, adipocyte · SINGLE PROTEIN · Homo sapiens

764Compounds
71Assays
0Approved Drugs
846.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Protein identity stays anchored to UniProt P15090. Use UniProt P15090 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt P15090 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Fatty acid-binding protein, adipocyte as ChEMBL target CHEMBL2083, mapped to UniProt P15090. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Fatty acid-binding protein, adipocyte
SINGLE PROTEIN · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL2083
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
P15090
Fatty acid-binding protein, adipocyte
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Fatty acid-binding protein, adipocyte is the right protein anchor across sources, using UniProt P15090 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelFatty acid-binding protein, adipocyte
UniProt AccessionP15090
Component TypeProtein
Sequence Length132 aa

Fatty acid-binding protein, adipocyte

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Fatty acid-binding protein, adipocyte, mapped to UniProt P15090. Sequence length is 132 aa.

Mapped IDP15090
Review nameFatty acid-binding protein, adipocyte
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

1
Phase III
4
Phase II
2
Phase I
Assay Mix

Activity Type Distribution

IC50637.0
KI172.0
KD37.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL5272139 10.0 Ki 0.1 Preclinical
CHEMBL247298 8.7 Ki 2.0 Preclinical
CHEMBL378857 8.6 Ki 2.5 Preclinical
CHEMBL245282 8.57 Ki 2.7 Preclinical
CHEMBL245284 8.48 Ki 3.3 Preclinical
CHEMBL245653 8.47 Ki 3.4 Preclinical
CHEMBL247529 8.46 Ki 3.5 Preclinical
CHEMBL247920 8.4 Kd 4.0 Preclinical
CHEMBL1782966 8.3 Ki 5.0 Preclinical
CHEMBL126078 8.22 Ki 6.0 Preclinical
Distribution

pChEMBL Value Distribution

117
5.0
126
5.5
140
6.0
99
6.5
84
7.0
93
7.5
32
8.0
3
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

72
Total Assays
644
Tested Compounds
1
Assay Types
Binding — 72 assays, 644 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 45 301 6.1
assay format 16 325 6.6
cell-based format 11 18 5.5

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine