Assay Detail
Functional
CHEMBL1120082
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Vasorelaxant activity in rat aortic ring assessed as inhibition of phenylephrine-induced contraction
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Aorta |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Substituted 2H-isoquinolin-1-ones as potent Rho-kinase inhibitors: part 3, aryl substituted pyrrolidines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 6.97 | 7.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1082821 | — | — | 1 | 7.64 |
| CHEMBL1082820 | — | — | 1 | 7.40 |
| CHEMBL1084324 | — | — | 1 | 7.26 |
| CHEMBL1082819 | — | — | 1 | 7.22 |
| CHEMBL1083747 | — | — | 1 | 7.20 |
| CHEMBL1084105 | — | — | 1 | 7.18 |
| CHEMBL1083748 | — | — | 1 | 7.06 |
| CHEMBL1084597 | — | — | 1 | 7.05 |
| CHEMBL1084653 | — | — | 1 | 6.85 |
| CHEMBL1084104 | — | — | 1 | 6.82 |
| CHEMBL1084110 | — | — | 1 | 6.80 |
| CHEMBL1084892 | — | — | 1 | 6.77 |
| CHEMBL1083800 | — | — | 1 | 6.68 |
| CHEMBL1085082 | — | — | 1 | 6.66 |
| CHEMBL1083113 | — | — | 1 | 6.60 |
| CHEMBL1085341 | — | — | 1 | 6.26 |
| CHEMBL1084800 | — | — | 1 | - |
| CHEMBL1083276 | — | — | 1 | - |
| CHEMBL1083799 | — | — | 1 | - |
| CHEMBL1084554 | — | — | 1 | - |
| CHEMBL1085773 | — | — | 1 | - |
| CHEMBL1084051 | — | — | 1 | - |
| CHEMBL1083749 | — | — | 1 | - |
| CHEMBL1084323 | — | — | 1 | - |
| CHEMBL1085342 | — | — | 1 | - |
| CHEMBL1085083 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1082821 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL1082820 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL1084324 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL1082819 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL1083747 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL1084105 | — | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL1083748 | — | IC50 | = | 88.0 | nM | 7.06 |
| CHEMBL1084597 | — | IC50 | = | 89.0 | nM | 7.05 |
| CHEMBL1084653 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL1084104 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL1084110 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL1084892 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL1083800 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL1085082 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL1083113 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL1085341 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL1084800 | — | IC50 | - | — | - | |
| CHEMBL1083276 | — | IC50 | - | — | - | |
| CHEMBL1083799 | — | IC50 | - | — | - | |
| CHEMBL1084554 | — | IC50 | - | — | - | |
| CHEMBL1085773 | — | IC50 | - | — | - | |
| CHEMBL1084051 | — | IC50 | - | — | - | |
| CHEMBL1083749 | — | IC50 | - | — | - | |
| CHEMBL1084323 | — | IC50 | - | — | - | |
| CHEMBL1085342 | — | IC50 | - | — | - | |
| CHEMBL1085083 | — | IC50 | - | — | - |