Assay Detail
Binding
CHEMBL1120091
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Inhibition of PDE11A
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A (CHEMBL2717) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of imidazo[1,5-a]pyrido[3,2-e]pyrazines as a new class of phosphodiesterase 10A inhibitiors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 6.64 | 7.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1085374 | — | — | 1 | 7.16 |
| CHEMBL1086110 | — | — | 1 | 6.11 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1085374 | — | IC50 | = | 68.6 | nM | 7.16 |
| CHEMBL1086110 | — | IC50 | = | 779.0 | nM | 6.11 |