Assay Detail
Functional
CHEMBL1120106
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Cytotoxicity against human A431 cells after 96 hrs by SRB assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A-431 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Carbamate derivatives of betulinic acid and betulin with selective cytotoxic activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 4.80 | 5.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1085718 | — | — | 1 | 5.30 |
| CHEMBL1085716 | BIS(ETHYLCARBAMATE)BETULIN | — | 1 | 5.22 |
| CHEMBL1080280 | — | — | 1 | 4.91 |
| CHEMBL269277 | BETULINIC ACID | 1.0 | 1 | 4.90 |
| CHEMBL1085714 | — | — | 1 | 4.83 |
| CHEMBL1085712 | — | — | 1 | 4.82 |
| CHEMBL295602 | METHYL BETULINATE | — | 1 | 4.57 |
| CHEMBL1085713 | — | — | 1 | 4.57 |
| CHEMBL1085715 | — | — | 1 | 4.04 |
| CHEMBL1085717 | BIS(PHENYLCARBAMATE)BETULIN | — | 1 | - |
| CHEMBL1085719 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1085718 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL1085716 | BIS(ETHYLCARBAMATE)BETULIN | IC50 | = | 6080.0 | nM | 5.22 |
| CHEMBL1080280 | — | IC50 | = | 12190.0 | nM | 4.91 |
| CHEMBL269277 | BETULINIC ACID | IC50 | = | 12600.0 | nM | 4.90 |
| CHEMBL1085714 | — | IC50 | = | 14800.0 | nM | 4.83 |
| CHEMBL1085712 | — | IC50 | = | 15200.0 | nM | 4.82 |
| CHEMBL295602 | METHYL BETULINATE | IC50 | = | 26990.0 | nM | 4.57 |
| CHEMBL1085713 | — | IC50 | = | 26710.0 | nM | 4.57 |
| CHEMBL1085715 | — | IC50 | = | 91450.0 | nM | 4.04 |
| CHEMBL1085717 | BIS(PHENYLCARBAMATE)BETULIN | IC50 | > | 100000.0 | nM | - |
| CHEMBL1085719 | — | IC50 | > | 100000.0 | nM | - |