Assay Detail
Binding
CHEMBL1120513
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of tetrodotoxin-sensitive sodium channel
24
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Second generation N-(1,2-diphenylethyl)piperazines as dual serotonin and noradrenaline reuptake inhibitors: improving metabolic stability and reducing ion channel activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 5.43 | 6.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL403441 | — | — | 1 | 6.10 |
| CHEMBL1084033 | 1-(1-(4-FLUOROPHENYL)-2-(2-(TRIFLUOROMETHOXY)PHENYL)ETHYL)PIPERAZINE (ENANTIOMERIC MIX) | — | 3 | 5.85 |
| CHEMBL1083426 | 1-(1-(2-FLUOROPHENYL)-2-(2-(TRIFLUOROMETHOXY)PHENYL)ETHYL)PIPERAZINE (ENANTIOMERIC MIX) | — | 2 | 5.85 |
| CHEMBL1086275 | — | — | 1 | 5.74 |
| CHEMBL375131 | — | — | 1 | 5.68 |
| CHEMBL1083708 | 1-(2-(2-(DIFLUOROMETHOXY)PHENYL)-1-PHENYLETHYL)PIPERAZINE (ENANTIOMERIC MIX) | — | 3 | 5.53 |
| CHEMBL1084309 | — | — | 1 | 5.47 |
| CHEMBL1083425 | — | — | 1 | 5.44 |
| CHEMBL1086273 | — | — | 1 | 5.42 |
| CHEMBL1085959 | — | — | 1 | 5.42 |
| CHEMBL1083427 | — | — | 1 | 5.40 |
| CHEMBL214335 | — | — | 3 | 5.35 |
| CHEMBL1085321 | — | — | 1 | 5.34 |
| CHEMBL1085567 | — | — | 1 | 5.32 |
| CHEMBL1080787 | — | — | 1 | 5.07 |
| CHEMBL1084971 | — | — | 1 | 4.94 |
| CHEMBL1084577 | — | — | 1 | 4.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL403441 | — | IC50 | = | 790.0 | nM | 6.10 |
| CHEMBL1084033 | 1-(1-(4-FLUOROPHENYL)-2-(2-(TRIFLUOROMETHOXY)PHENYL)ETHYL)PIPERAZINE (ENANTIOMERIC MIX) | IC50 | = | 1420.0 | nM | 5.85 |
| CHEMBL1083426 | 1-(1-(2-FLUOROPHENYL)-2-(2-(TRIFLUOROMETHOXY)PHENYL)ETHYL)PIPERAZINE (ENANTIOMERIC MIX) | IC50 | = | 1410.0 | nM | 5.85 |
| CHEMBL1086275 | — | IC50 | = | 1830.0 | nM | 5.74 |
| CHEMBL375131 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL1084033 | 1-(1-(4-FLUOROPHENYL)-2-(2-(TRIFLUOROMETHOXY)PHENYL)ETHYL)PIPERAZINE (ENANTIOMERIC MIX) | IC50 | = | 2960.0 | nM | 5.53 |
| CHEMBL1083708 | 1-(2-(2-(DIFLUOROMETHOXY)PHENYL)-1-PHENYLETHYL)PIPERAZINE (ENANTIOMERIC MIX) | IC50 | = | 2970.0 | nM | 5.53 |
| CHEMBL1084033 | 1-(1-(4-FLUOROPHENYL)-2-(2-(TRIFLUOROMETHOXY)PHENYL)ETHYL)PIPERAZINE (ENANTIOMERIC MIX) | IC50 | = | 3140.0 | nM | 5.50 |
| CHEMBL1083426 | 1-(1-(2-FLUOROPHENYL)-2-(2-(TRIFLUOROMETHOXY)PHENYL)ETHYL)PIPERAZINE (ENANTIOMERIC MIX) | IC50 | = | 3270.0 | nM | 5.49 |
| CHEMBL1084309 | — | IC50 | = | 3370.0 | nM | 5.47 |
| CHEMBL1083425 | — | IC50 | = | 3660.0 | nM | 5.44 |
| CHEMBL1085959 | — | IC50 | = | 3840.0 | nM | 5.42 |
| CHEMBL1086273 | — | IC50 | = | 3810.0 | nM | 5.42 |
| CHEMBL1083427 | — | IC50 | = | 3990.0 | nM | 5.40 |
| CHEMBL214335 | — | IC50 | = | 4470.0 | nM | 5.35 |
| CHEMBL1085321 | — | IC50 | = | 4540.0 | nM | 5.34 |
| CHEMBL1083708 | 1-(2-(2-(DIFLUOROMETHOXY)PHENYL)-1-PHENYLETHYL)PIPERAZINE (ENANTIOMERIC MIX) | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL1085567 | — | IC50 | = | 4830.0 | nM | 5.32 |
| CHEMBL1083708 | 1-(2-(2-(DIFLUOROMETHOXY)PHENYL)-1-PHENYLETHYL)PIPERAZINE (ENANTIOMERIC MIX) | IC50 | = | 4890.0 | nM | 5.31 |
| CHEMBL214335 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL1080787 | — | IC50 | = | 8550.0 | nM | 5.07 |
| CHEMBL214335 | — | IC50 | = | 8740.0 | nM | 5.06 |
| CHEMBL1084971 | — | IC50 | = | 11500.0 | nM | 4.94 |
| CHEMBL1084577 | — | IC50 | = | 15200.0 | nM | 4.82 |