Compound Detail
CHEMBL1085321
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Basic Information
| ChEMBL ID | CHEMBL1085321 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | WHMNJJQFCNBWSW-UHFFFAOYSA-N |
4
Targets
4
Activities
2
Assay Types
1
PK Parameters
6
Publications
0
Known Names
Molecular Properties
314.4
MW (Da)
3.02
ALogP
3
HBA
1
HBD
24.5
PSA (Ų)
0.92
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 3 meas. best 8.1
IC50 1 meas. best 5.34
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Sodium-dependent serotonin transporter CHEMBL228 | Ki | 8.1 | 8.1 | 8.0 | 1 |
| Sodium-dependent noradrenaline transporter CHEMBL222 | Ki | 7.52 | 7.52 | 30.0 | 1 |
| Sodium-dependent dopamine transporter CHEMBL238 | Ki | 5.39 | 5.39 | 4060.0 | 1 |
| Unchecked CHEMBL612545 | IC50 | 5.34 | 5.34 | 4540.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| T1/2 | 2.0 | hr | Homo sapiens |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Sodium-dependent serotonin transporter | Ki | = | 8.0 | nM | 8.1 | Displacement of [3H]citalopram from human SERT expressed in HEK293 cells by scin... | 20471260 |
| Sodium-dependent noradrenaline transporter | Ki | = | 30.0 | nM | 7.52 | Displacement of [3H]nisoxetine from human NET expressed in HEK293 cells by scint... | 20471260 |
| Sodium-dependent dopamine transporter | Ki | = | 4060.0 | nM | 5.39 | Displacement of [3H]dopamine from human DAT expressed in HEK293 cells by scintil... | 20471260 |
| Unchecked | IC50 | = | 4540.0 | nM | 5.34 | Inhibition of tetrodotoxin-sensitive sodium channel | 20471260 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 20471260 | 10.1016/j.bmcl.2010.04.052 | Sodium-dependent serotonin transporter | 1 |
| 20471260 | 10.1016/j.bmcl.2010.04.052 | Sodium-dependent noradrenaline transporter | 1 |
| 20471260 | 10.1016/j.bmcl.2010.04.052 | Sodium-dependent dopamine transporter | 1 |
| 20471260 | 10.1016/j.bmcl.2010.04.052 | Voltage-gated inwardly rectifying potassium channel KCNH2 | 1 |
| 20471260 | 10.1016/j.bmcl.2010.04.052 | Liver microsomes | 1 |
| 20471260 | 10.1016/j.bmcl.2010.04.052 | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine