Assay Detail
Functional
CHEMBL1120541
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Agonist activity at human TLR7 expressed in NF-kappaB-stimulated HEK293 cells assessed as induction of secreted alkaline phosphatase expression by reporter gene assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structure-activity relationships in human toll-like receptor 7-active imidazoquinoline analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 18 | 6.23 | 8.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1082983 | — | — | 1 | 8.07 |
| CHEMBL1086473 | — | — | 1 | 7.23 |
| CHEMBL1086474 | — | — | 1 | 7.04 |
| CHEMBL1082642 | — | — | 1 | 6.68 |
| CHEMBL1082399 | — | — | 1 | 6.58 |
| CHEMBL1082982 | — | — | 1 | 6.42 |
| CHEMBL1083637 | — | — | 1 | 6.33 |
| CHEMBL1082376 | — | — | 1 | 6.32 |
| CHEMBL1086143 | — | — | 1 | 6.19 |
| CHEMBL1082307 | — | — | 1 | 6.14 |
| CHEMBL1086372 | — | — | 1 | 6.08 |
| CHEMBL1082336 | — | — | 1 | 6.06 |
| CHEMBL1082304 | — | — | 1 | 6.02 |
| CHEMBL1085742 | — | — | 1 | 5.70 |
| CHEMBL1282 | IMIQUIMOD | 4.0 | 1 | 5.67 |
| CHEMBL1083026 | — | — | 1 | 5.47 |
| CHEMBL1082364 | — | — | 1 | 5.11 |
| CHEMBL1084998 | — | — | 1 | 5.08 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1082983 | — | EC50 | = | 8.58 | nM | 8.07 |
| CHEMBL1086473 | — | EC50 | = | 59.1 | nM | 7.23 |
| CHEMBL1086474 | — | EC50 | = | 91.5 | nM | 7.04 |
| CHEMBL1082642 | — | EC50 | = | 209.0 | nM | 6.68 |
| CHEMBL1082399 | — | EC50 | = | 262.0 | nM | 6.58 |
| CHEMBL1082982 | — | EC50 | = | 385.0 | nM | 6.42 |
| CHEMBL1083637 | — | EC50 | = | 472.0 | nM | 6.33 |
| CHEMBL1082376 | — | EC50 | = | 479.0 | nM | 6.32 |
| CHEMBL1086143 | — | EC50 | = | 647.0 | nM | 6.19 |
| CHEMBL1082307 | — | EC50 | = | 723.0 | nM | 6.14 |
| CHEMBL1086372 | — | EC50 | = | 822.0 | nM | 6.08 |
| CHEMBL1082336 | — | EC50 | = | 873.0 | nM | 6.06 |
| CHEMBL1082304 | — | EC50 | = | 955.0 | nM | 6.02 |
| CHEMBL1085742 | — | EC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL1282 | IMIQUIMOD | EC50 | = | 2120.0 | nM | 5.67 |
| CHEMBL1083026 | — | EC50 | = | 3350.0 | nM | 5.47 |
| CHEMBL1082364 | — | EC50 | = | 7710.0 | nM | 5.11 |
| CHEMBL1084998 | — | EC50 | = | 8390.0 | nM | 5.08 |