Compound Detail
CHEMBL1282
IMIQUIMOD 💊 Approved Drug
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💊 Approved Drug
Basic Information
| ChEMBL ID | CHEMBL1282 |
| Name | IMIQUIMOD |
| Phase | Approved |
| Structure Type | MOL |
| InChI Key | DOUYETYNHWVLEO-UHFFFAOYSA-N |
| Therapeutic | ✓ Yes |
9
Targets
25
Activities
3
Assay Types
0
PK Parameters
20
Publications
10
Known Names
20
Indications
1
Mechanisms
Molecular Properties
240.3
MW (Da)
2.82
ALogP
4
HBA
1
HBD
56.7
PSA (Ų)
0.75
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| First Approval | 1997 |
| Availability | Prescription |
| Chirality | Achiral |
Mechanism of Action
| Mechanism | Action Type | Target | Direct | Efficacy |
|---|---|---|---|---|
| Toll-like receptor 7 agonist | AGONIST | Toll-like receptor 7 | ✓ | ✓ |
Indications
Carcinoma, Basal Cell Carcinoma, Basal Cell Condylomata Acuminata Keratosis Keratosis, Actinic Keratosis, Actinic Virus Diseases Influenza, Human Leishmaniasis, Cutaneous Paget Disease, Extramammary Papillomavirus Infections Scleroderma, Localized Squamous Intraepithelial Lesions Uterine Cervical Dysplasia Uterine Cervical Dysplasia Vulvar Neoplasms Bowen's Disease Breast Neoplasms Carcinoma in Situ Carcinoma, Non-Small-Cell Lung
ATC Classification
D06BB10
imiquimod
Level 1: DERMATOLOGICALS
Level 2: ANTIBIOTICS AND CHEMOTHERAPEUTICS FOR DERMATOLOGICAL USE
Drug Warnings
Black Box Warning
General Warning
Activity Summary
EC50 11 meas. best 6.7
IC50 11 meas. best 6.19
Ki 3 meas. best 5.89
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Toll-like receptor 7 CHEMBL5936 | EC50 | 6.7 | 5.399 | 202.0 | 10 |
| Oxidized purine nucleoside triphosphate hydrolase CHEMBL3708265 | IC50 | 6.19 | 6.19 | 646.0 | 1 |
| Hepatitis C virus CHEMBL379 | EC50 | 6.0 | 6.0 | 1000.0 | 1 |
| Alpha-1D adrenergic receptor CHEMBL223 | Ki | 5.89 | 5.89 | 1288.0 | 1 |
| Histamine H2 receptor CHEMBL1941 | Ki | 5.83 | 5.83 | 1481.0 | 1 |
| Histamine H2 receptor CHEMBL1941 | IC50 | 5.82 | 5.82 | 1506.0 | 1 |
| Alpha-1D adrenergic receptor CHEMBL223 | IC50 | 5.58 | 5.58 | 2621.0 | 1 |
| Adenosine receptor A2a CHEMBL251 | Ki | 5.53 | 5.53 | 2987.0 | 1 |
| Adenosine receptor A2a CHEMBL251 | IC50 | 5.27 | 5.27 | 5320.0 | 1 |
| NON-PROTEIN TARGET CHEMBL3879801 | IC50 | 4.47 | 4.37 | 33500.0 | 2 |
| LS174T CHEMBL614097 | IC50 | 4.46 | 4.46 | 34400.0 | 1 |
| A-375 CHEMBL613859 | IC50 | 4.15 | 4.15 | 70300.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
Literature References
Data from ChEMBL 36 via Core Engine