Assay Detail
Functional
CHEMBL2216965
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human TLR7 transfected in HEK cells assessed as NFkappaB induction after 24 hrs by specific secreted alkaline phosphatase gene assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of Imidazoquinolines with Toll-Like Receptor 7/8 Independent Cytokine Induction.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 5.54 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1082983 | — | — | 1 | 7.00 |
| CHEMBL2216760 | — | — | 1 | 5.92 |
| CHEMBL383322 | RESIQUIMOD | 2.0 | 1 | 5.85 |
| CHEMBL1282 | IMIQUIMOD | 4.0 | 1 | 4.92 |
| CHEMBL195276 | — | — | 1 | 4.02 |
| CHEMBL2216759 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1082983 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL2216760 | — | EC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL383322 | RESIQUIMOD | EC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL1282 | IMIQUIMOD | EC50 | = | 12100.0 | nM | 4.92 |
| CHEMBL195276 | — | EC50 | = | 95000.0 | nM | 4.02 |
| CHEMBL2216759 | — | EC50 | > | 270000.0 | nM | - |