Assay Detail
Binding
CHEMBL4136300
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Agonist activity at human TLR7 expressed in HEK cells after 8 to 12 hrs by NFkappaB/SEAP reporter gene assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design and Synthesis of N1-Modified Imidazoquinoline Agonists for Selective Activation of Toll-like Receptors 7 and 8.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 19 | 5.58 | 6.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4170901 | — | — | 1 | 6.75 |
| CHEMBL4162974 | — | — | 1 | 6.22 |
| CHEMBL383322 | RESIQUIMOD | 2.0 | 1 | 5.87 |
| CHEMBL2216760 | — | — | 1 | 5.77 |
| CHEMBL4174580 | — | — | 1 | 5.76 |
| CHEMBL4160925 | — | — | 1 | 5.76 |
| CHEMBL3116322 | — | — | 1 | 5.65 |
| CHEMBL4169848 | — | — | 1 | 5.54 |
| CHEMBL4164327 | — | — | 1 | 5.54 |
| CHEMBL4161057 | — | — | 1 | 5.51 |
| CHEMBL4172215 | — | — | 1 | 5.49 |
| CHEMBL4165438 | — | — | 1 | 5.48 |
| CHEMBL4176050 | — | — | 1 | 5.44 |
| CHEMBL4161998 | — | — | 1 | 5.42 |
| CHEMBL4163927 | — | — | 1 | 5.34 |
| CHEMBL4172654 | — | — | 1 | 5.18 |
| CHEMBL1282 | IMIQUIMOD | 4.0 | 1 | 4.94 |
| CHEMBL3116325 | — | — | 1 | 4.84 |
| CHEMBL4166427 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4170901 | — | EC50 | = | 180.0 | nM | 6.75 |
| CHEMBL4162974 | — | EC50 | = | 600.0 | nM | 6.22 |
| CHEMBL383322 | RESIQUIMOD | EC50 | = | 1340.0 | nM | 5.87 |
| CHEMBL2216760 | — | EC50 | = | 1690.0 | nM | 5.77 |
| CHEMBL4174580 | — | EC50 | = | 1740.0 | nM | 5.76 |
| CHEMBL4160925 | — | EC50 | = | 1720.0 | nM | 5.76 |
| CHEMBL3116322 | — | EC50 | = | 2220.0 | nM | 5.65 |
| CHEMBL4169848 | — | EC50 | = | 2890.0 | nM | 5.54 |
| CHEMBL4164327 | — | EC50 | = | 2890.0 | nM | 5.54 |
| CHEMBL4161057 | — | EC50 | = | 3060.0 | nM | 5.51 |
| CHEMBL4172215 | — | EC50 | = | 3210.0 | nM | 5.49 |
| CHEMBL4165438 | — | EC50 | = | 3330.0 | nM | 5.48 |
| CHEMBL4176050 | — | EC50 | = | 3640.0 | nM | 5.44 |
| CHEMBL4161998 | — | EC50 | = | 3840.0 | nM | 5.42 |
| CHEMBL4163927 | — | EC50 | = | 4530.0 | nM | 5.34 |
| CHEMBL4172654 | — | EC50 | = | 6670.0 | nM | 5.18 |
| CHEMBL1282 | IMIQUIMOD | EC50 | = | 11400.0 | nM | 4.94 |
| CHEMBL3116325 | — | EC50 | = | 14370.0 | nM | 4.84 |
| CHEMBL4166427 | — | EC50 | = | 190000.0 | nM | - |