Assay Detail
Functional
CHEMBL4602774
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HCV
41
Total Activities
41
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Hepacivirus hominis |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
A review on HCV inhibitors: Significance of non-structural polyproteins.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 40 | 6.88 | 9.08 |
| IC50 | 1 | 8.52 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3121846 | — | — | 1 | 9.08 |
| CHEMBL2105735 | ASUNAPREVIR | 4.0 | 1 | 9.00 |
| CHEMBL4642630 | — | — | 1 | 9.00 |
| CHEMBL4525964 | VANIPREVIR | 3.0 | 1 | 8.52 |
| CHEMBL4638630 | — | — | 1 | 8.40 |
| CHEMBL245328 | — | — | 1 | 8.12 |
| CHEMBL2063090 | GRAZOPREVIR ANHYDROUS | 4.0 | 1 | 8.02 |
| CHEMBL297884 | CILUPREVIR | 2.0 | 1 | 8.02 |
| CHEMBL4641917 | — | — | 1 | 7.96 |
| CHEMBL258734 | DANOPREVIR | 3.0 | 1 | 7.76 |
| CHEMBL2011266 | — | — | 1 | 7.70 |
| CHEMBL4638107 | — | — | 1 | 7.54 |
| CHEMBL4635161 | — | — | 1 | 7.42 |
| CHEMBL1255891 | NARLAPREVIR | 3.0 | 1 | 7.40 |
| CHEMBL4637704 | — | — | 1 | 7.30 |
| CHEMBL4638877 | — | — | 1 | 7.28 |
| CHEMBL2043025 | TMC-647055 | 2.0 | 1 | 7.09 |
| CHEMBL2181776 | BILB-1941 | 1.0 | 1 | 7.08 |
| CHEMBL4646449 | — | — | 1 | 7.05 |
| CHEMBL4644421 | — | — | 1 | 6.92 |
| CHEMBL4643906 | — | — | 1 | 6.89 |
| CHEMBL480816 | — | — | 1 | 6.85 |
| CHEMBL3422107 | — | — | 1 | 6.82 |
| CHEMBL3125400 | — | — | 1 | 6.75 |
| CHEMBL1783101 | — | — | 1 | 6.62 |
| CHEMBL390883 | — | — | 1 | 6.57 |
| CHEMBL4643189 | — | — | 1 | 6.50 |
| CHEMBL217625 | — | — | 1 | 6.40 |
| CHEMBL4633554 | — | — | 1 | 6.40 |
| CHEMBL4646177 | — | — | 1 | 6.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3121846 | — | EC50 | = | 0.83 | nM | 9.08 |
| CHEMBL2105735 | ASUNAPREVIR | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL4642630 | — | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL4525964 | VANIPREVIR | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL4638630 | — | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL245328 | — | EC50 | = | 7.6 | nM | 8.12 |
| CHEMBL2063090 | GRAZOPREVIR ANHYDROUS | EC50 | = | 9.5 | nM | 8.02 |
| CHEMBL297884 | CILUPREVIR | EC50 | = | 9.5 | nM | 8.02 |
| CHEMBL4641917 | — | EC50 | = | 11.0 | nM | 7.96 |
| CHEMBL258734 | DANOPREVIR | EC50 | = | 17.5 | nM | 7.76 |
| CHEMBL2011266 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL4638107 | — | EC50 | = | 29.0 | nM | 7.54 |
| CHEMBL4635161 | — | EC50 | = | 38.0 | nM | 7.42 |
| CHEMBL1255891 | NARLAPREVIR | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL4637704 | — | EC50 | = | 50.0 | nM | 7.30 |
| CHEMBL4638877 | — | EC50 | = | 52.0 | nM | 7.28 |
| CHEMBL2043025 | TMC-647055 | EC50 | = | 82.0 | nM | 7.09 |
| CHEMBL2181776 | BILB-1941 | EC50 | = | 84.0 | nM | 7.08 |
| CHEMBL4646449 | — | EC50 | = | 90.0 | nM | 7.05 |
| CHEMBL4644421 | — | EC50 | = | 120.0 | nM | 6.92 |
| CHEMBL4643906 | — | EC50 | = | 130.0 | nM | 6.89 |
| CHEMBL480816 | — | EC50 | = | 140.0 | nM | 6.85 |
| CHEMBL3422107 | — | EC50 | = | 150.0 | nM | 6.82 |
| CHEMBL3125400 | — | EC50 | = | 180.0 | nM | 6.75 |
| CHEMBL1783101 | — | EC50 | = | 240.0 | nM | 6.62 |
| CHEMBL390883 | — | EC50 | = | 270.0 | nM | 6.57 |
| CHEMBL4643189 | — | EC50 | = | 320.0 | nM | 6.50 |
| CHEMBL217625 | — | EC50 | = | 400.0 | nM | 6.40 |
| CHEMBL4633554 | — | EC50 | = | 400.0 | nM | 6.40 |
| CHEMBL4646177 | — | EC50 | = | 800.0 | nM | 6.10 |
| CHEMBL179532 | — | EC50 | = | 800.0 | nM | 6.10 |
| CHEMBL1282 | IMIQUIMOD | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL388502 | — | EC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL1087567 | — | EC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL1814457 | — | EC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL213832 | — | EC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL4636786 | — | EC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL223720 | — | EC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL210884 | — | EC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL549344 | CPG-52852 | EC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL1760434 | — | EC50 | = | 102000.0 | nM | - |