Assay Detail
Binding
CHEMBL4354073
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Agonist activity at human TLR7 in HEK293 cells cotransfected with SEAP reporter gene assessed as activity of SEAP incubated for 24 hrs by quanti-blue staining based SEAP reporter gene assay
38
Total Activities
38
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Selective Toll-like receptor 7 agonists with novel chromeno[3,4-d]imidazol-4(1H)-one and 2-(trifluoromethyl)quinoline/ quinazoline-4-amine scaffolds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 38 | 4.91 | 5.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4455899 | — | — | 1 | 5.75 |
| CHEMBL4456944 | — | — | 1 | 5.40 |
| CHEMBL4448786 | — | — | 1 | 5.36 |
| CHEMBL1282 | IMIQUIMOD | 4.0 | 1 | 5.21 |
| CHEMBL4459885 | — | — | 1 | 5.20 |
| CHEMBL3485054 | — | — | 1 | 5.08 |
| CHEMBL3486744 | — | — | 1 | 4.96 |
| CHEMBL4590302 | — | — | 1 | 4.82 |
| CHEMBL4440495 | — | — | 1 | 4.81 |
| CHEMBL4455751 | — | — | 1 | 4.78 |
| CHEMBL4558078 | — | — | 1 | 4.52 |
| CHEMBL4514055 | — | — | 1 | 4.36 |
| CHEMBL4473706 | — | — | 1 | 4.24 |
| CHEMBL4579626 | — | — | 1 | 4.18 |
| CHEMBL4448532 | — | — | 1 | - |
| CHEMBL4443048 | — | — | 1 | - |
| CHEMBL4544843 | — | — | 1 | - |
| CHEMBL4473510 | — | — | 1 | - |
| CHEMBL4436280 | — | — | 1 | - |
| CHEMBL4559927 | — | — | 1 | - |
| CHEMBL4447633 | — | — | 1 | - |
| CHEMBL4475558 | — | — | 1 | - |
| CHEMBL4578798 | — | — | 1 | - |
| CHEMBL4447055 | — | — | 1 | - |
| CHEMBL4468936 | — | — | 1 | - |
| CHEMBL1533585 | — | — | 1 | - |
| CHEMBL4524791 | — | — | 1 | - |
| CHEMBL4524487 | — | — | 1 | - |
| CHEMBL4469852 | — | — | 1 | - |
| CHEMBL4575133 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4455899 | — | EC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL4456944 | — | EC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL4448786 | — | EC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL1282 | IMIQUIMOD | EC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL4459885 | — | EC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL3485054 | — | EC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL3486744 | — | EC50 | = | 10900.0 | nM | 4.96 |
| CHEMBL4590302 | — | EC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL4440495 | — | EC50 | = | 15400.0 | nM | 4.81 |
| CHEMBL4455751 | — | EC50 | = | 16800.0 | nM | 4.78 |
| CHEMBL4558078 | — | EC50 | = | 29900.0 | nM | 4.52 |
| CHEMBL4514055 | — | EC50 | = | 44000.0 | nM | 4.36 |
| CHEMBL4473706 | — | EC50 | = | 57400.0 | nM | 4.24 |
| CHEMBL4579626 | — | EC50 | = | 66600.0 | nM | 4.18 |
| CHEMBL4566426 | — | EC50 | - | — | - | |
| CHEMBL4453744 | — | EC50 | - | — | - | |
| CHEMBL4452563 | — | EC50 | - | — | - | |
| CHEMBL1337329 | — | EC50 | - | — | - | |
| CHEMBL4547147 | — | EC50 | - | — | - | |
| CHEMBL4554195 | — | EC50 | - | — | - | |
| CHEMBL4533565 | — | EC50 | - | — | - | |
| CHEMBL4463104 | — | EC50 | = | 114000.0 | nM | - |
| CHEMBL4448532 | — | EC50 | = | 279000.0 | nM | - |
| CHEMBL4443048 | — | EC50 | - | — | - | |
| CHEMBL4544843 | — | EC50 | - | — | - | |
| CHEMBL4473510 | — | EC50 | - | — | - | |
| CHEMBL4436280 | — | EC50 | - | — | - | |
| CHEMBL4559927 | — | EC50 | = | 535000.0 | nM | - |
| CHEMBL4447633 | — | EC50 | - | — | - | |
| CHEMBL4475558 | — | EC50 | - | — | - | |
| CHEMBL4578798 | — | EC50 | - | — | - | |
| CHEMBL4447055 | — | EC50 | = | 107000.0 | nM | - |
| CHEMBL4468936 | — | EC50 | - | — | - | |
| CHEMBL1533585 | — | EC50 | - | — | - | |
| CHEMBL4524791 | — | EC50 | - | — | - | |
| CHEMBL4524487 | — | EC50 | - | — | - | |
| CHEMBL4469852 | — | EC50 | - | — | - | |
| CHEMBL4575133 | — | EC50 | - | — | - |