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Assay Detail

CHEMBL5342184

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Agonist activity at TLR7 (unknown origin)
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Toll-like receptor 7 (CHEMBL5936)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Small-Molecule Modulators Targeting Toll-like Receptors for Potential Anticancer Therapeutics.
Wang J, Zhang J, Wang J, Hu X, Ouyang L, Wang Y.
J Med Chem (2023) 66 : 6437 -6462
PubMed 37163340 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 18 6.50 8.07

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1082983 1 8.07
CHEMBL5435648 1 7.80
CHEMBL1086473 1 7.23
CHEMBL5397718 1 7.07
CHEMBL210884 1 6.85
CHEMBL5268440 1 6.80
CHEMBL5400758 1 6.72
CHEMBL5276534 1 6.58
CHEMBL5406749 1 6.57
CHEMBL5430530 1 6.26
CHEMBL5272163 1 6.07
CHEMBL383322 RESIQUIMOD 2.0 1 5.82
CHEMBL1085742 1 5.70
CHEMBL1282 IMIQUIMOD 4.0 1 5.67
CHEMBL5397171 1 4.36
CHEMBL549344 CPG-52852 2.0 1 -
CHEMBL5418815 1 -
CHEMBL5415035 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1082983 EC50 = 8.58 nM 8.07
CHEMBL5435648 EC50 = 16.0 nM 7.80
CHEMBL1086473 EC50 = 59.1 nM 7.23
CHEMBL5397718 EC50 = 85.0 nM 7.07
CHEMBL210884 EC50 = 140.0 nM 6.85
CHEMBL5268440 EC50 = 160.0 nM 6.80
CHEMBL5400758 EC50 = 190.0 nM 6.72
CHEMBL5276534 EC50 = 260.0 nM 6.58
CHEMBL5406749 EC50 = 270.0 nM 6.57
CHEMBL5430530 EC50 = 550.0 nM 6.26
CHEMBL5272163 EC50 = 860.0 nM 6.07
CHEMBL383322 RESIQUIMOD EC50 = 1500.0 nM 5.82
CHEMBL1085742 EC50 = 2000.0 nM 5.70
CHEMBL1282 IMIQUIMOD EC50 = 2120.0 nM 5.67
CHEMBL5397171 EC50 = 44000.0 nM 4.36
CHEMBL549344 CPG-52852 EC50 ~ 3000.0 nM -
CHEMBL5418815 EC50 > 100.0 nM -
CHEMBL5415035 EC50 > 100.0 nM -