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Compound Detail

CHEMBL5268440

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CCCCOc1nc(N)c2[nH]cc(Cc3ccc(CN4CCCC4)cc3)c2n1

Basic Information

ChEMBL ID CHEMBL5268440
Phase Preclinical
Structure Type MOL
InChI Key VMDGIQUJSYPMLF-UHFFFAOYSA-N
1
Targets
3
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names

Molecular Properties

379.5
MW (Da)
3.91
ALogP
5
HBA
2
HBD
80.1
PSA (Ų)
0.58
QED
0
Ro5 Violations
8
Rot. Bonds

Drug Information

Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C22H29N5O
MW 379.51
Aromatic Rings 3
Heavy Atoms 28
NP-Likeness -0.56

Activity Summary

EC50 3 meas. best 8.26

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Toll-like receptor 7
CHEMBL5936
EC50 8.26 7.3533 5.5 3

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
34355178 10.1039/D1MD00031D Toll-like receptor 7 1
37163340 10.1021/acs.jmedchem.2c01655 Toll-like receptor 7 1

Data from ChEMBL 36 via Core Engine