Assay Detail
Binding
CHEMBL5244351
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Agonist activity at TLR7 (unknown origin)
17
Total Activities
17
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structural evolution of toll-like receptor 7/8 agonists from imidazoquinolines to imidazoles.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 15 | 6.17 | 9.00 |
| MEC | 2 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5278024 | — | — | 1 | 9.00 |
| CHEMBL5275885 | — | — | 1 | 7.52 |
| CHEMBL5268440 | — | — | 1 | 7.00 |
| CHEMBL5273911 | — | — | 1 | 6.77 |
| CHEMBL5280595 | — | — | 1 | 6.62 |
| CHEMBL5285197 | — | — | 1 | 6.18 |
| CHEMBL5267126 | — | — | 1 | 6.12 |
| CHEMBL5281452 | — | — | 1 | 5.77 |
| CHEMBL5282657 | — | — | 1 | 5.53 |
| CHEMBL5276805 | — | — | 1 | 5.53 |
| CHEMBL5270391 | — | — | 1 | 5.32 |
| CHEMBL5275220 | — | — | 1 | 5.11 |
| CHEMBL5269895 | — | — | 1 | 5.08 |
| CHEMBL5281596 | — | — | 1 | 4.76 |
| CHEMBL5272274 | — | — | 1 | - |
| CHEMBL5285458 | — | — | 1 | - |
| CHEMBL5266746 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5278024 | — | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL5275885 | — | EC50 | = | 30.0 | nM | 7.52 |
| CHEMBL5268440 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL5273911 | — | EC50 | = | 170.0 | nM | 6.77 |
| CHEMBL5280595 | — | EC50 | = | 240.0 | nM | 6.62 |
| CHEMBL5285197 | — | EC50 | = | 660.0 | nM | 6.18 |
| CHEMBL5267126 | — | EC50 | = | 750.0 | nM | 6.12 |
| CHEMBL5281452 | — | EC50 | = | 1710.0 | nM | 5.77 |
| CHEMBL5282657 | — | EC50 | = | 2940.0 | nM | 5.53 |
| CHEMBL5276805 | — | EC50 | = | 2940.0 | nM | 5.53 |
| CHEMBL5270391 | — | EC50 | = | 4750.0 | nM | 5.32 |
| CHEMBL5275220 | — | EC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL5269895 | — | EC50 | = | 8270.0 | nM | 5.08 |
| CHEMBL5281596 | — | EC50 | = | 17490.0 | nM | 4.76 |
| CHEMBL5272274 | — | EC50 | > | 25000.0 | nM | - |
| CHEMBL5285458 | — | MEC | = | 0.18 | uM | - |
| CHEMBL5266746 | — | MEC | = | 2.0 | uM | - |