Compound Detail
CHEMBL5269895
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Basic Information
| ChEMBL ID | CHEMBL5269895 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | JCUYXKMVIIUJGB-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
225.3
MW (Da)
1.45
ALogP
6
HBA
2
HBD
86.0
PSA (Ų)
0.71
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 2 meas. best 6.34
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Toll-like receptor 8 CHEMBL5805 | EC50 | 6.34 | 6.34 | 460.0 | 1 |
| Toll-like receptor 7 CHEMBL5936 | EC50 | 5.08 | 5.08 | 8270.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Toll-like receptor 8 | EC50 | = | 460.0 | nM | 6.34 | Agonist activity at TLR8 (unknown origin) | 34355178 |
| Toll-like receptor 7 | EC50 | = | 8270.0 | nM | 5.08 | Agonist activity at TLR7 (unknown origin) | 34355178 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 34355178 | 10.1039/D1MD00031D | Toll-like receptor 8 | 1 |
| 34355178 | 10.1039/D1MD00031D | Toll-like receptor 7 | 1 |
Data from ChEMBL 36 via Core Engine