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Compound Detail

CHEMBL5285197

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CCCCNc1nc(N)nnc1OCc1ccccc1OC

Basic Information

ChEMBL ID CHEMBL5285197
Phase Preclinical
Structure Type MOL
InChI Key QXJSCXMHKKWNJW-UHFFFAOYSA-N
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names

Molecular Properties

303.4
MW (Da)
2.25
ALogP
7
HBA
2
HBD
95.2
PSA (Ų)
0.72
QED
0
Ro5 Violations
8
Rot. Bonds

Drug Information

Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C15H21N5O2
MW 303.37
Aromatic Rings 2
Heavy Atoms 22
NP-Likeness -0.99

Activity Summary

EC50 2 meas. best 6.19

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Toll-like receptor 8
CHEMBL5805
EC50 6.19 6.19 640.0 1
Toll-like receptor 7
CHEMBL5936
EC50 6.18 6.18 660.0 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Toll-like receptor 8 EC50 = 640.0 nM 6.19 Agonist activity at TLR8 (unknown origin) 34355178
Toll-like receptor 7 EC50 = 660.0 nM 6.18 Agonist activity at TLR7 (unknown origin) 34355178

Literature References

PubMed DOI Target Context # Activities
34355178 10.1039/D1MD00031D Toll-like receptor 8 1
34355178 10.1039/D1MD00031D Toll-like receptor 7 1

Data from ChEMBL 36 via Core Engine