Assay Detail
Binding
CHEMBL3116709
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Agonist activity at human TLR-7 expressed in HEK293 cells after 24 hrs by SEAP reporter gene assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structure-activity relationship analysis of imidazoquinolines with Toll-like receptors 7 and 8 selectivity and enhanced cytokine induction.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 15 | 5.20 | 5.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2216760 | — | — | 1 | 5.82 |
| CHEMBL383322 | RESIQUIMOD | 2.0 | 1 | 5.82 |
| CHEMBL3116315 | — | — | 1 | 5.62 |
| CHEMBL3116320 | — | — | 1 | 5.58 |
| CHEMBL3116323 | — | — | 1 | 5.54 |
| CHEMBL3116322 | — | — | 1 | 5.48 |
| CHEMBL3116324 | — | — | 1 | 5.36 |
| CHEMBL3116321 | — | — | 1 | 5.32 |
| CHEMBL3116316 | — | — | 1 | 5.24 |
| CHEMBL1282 | IMIQUIMOD | 4.0 | 1 | 4.97 |
| CHEMBL3116325 | — | — | 1 | 4.64 |
| CHEMBL3116319 | — | — | 1 | 4.62 |
| CHEMBL3116318 | — | — | 1 | 4.54 |
| CHEMBL3116317 | — | — | 1 | 4.31 |
| CHEMBL2216759 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2216760 | — | EC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL383322 | RESIQUIMOD | EC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL3116315 | — | EC50 | = | 2420.0 | nM | 5.62 |
| CHEMBL3116320 | — | EC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL3116323 | — | EC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL3116322 | — | EC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL3116324 | — | EC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL3116321 | — | EC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL3116316 | — | EC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL1282 | IMIQUIMOD | EC50 | = | 10700.0 | nM | 4.97 |
| CHEMBL3116325 | — | EC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL3116319 | — | EC50 | = | 23800.0 | nM | 4.62 |
| CHEMBL3116318 | — | EC50 | = | 29100.0 | nM | 4.54 |
| CHEMBL3116317 | — | EC50 | = | 49200.0 | nM | 4.31 |
| CHEMBL2216759 | — | EC50 | - | — | - |