Assay Detail
Functional
CHEMBL1120800
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Inhibition of IBMECA-mediated human U87MG cell proliferation after 48 hrs by trypan blue exclusion assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | U-87MG ATCC |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel N2-substituted pyrazolo[3,4-d]pyrimidine adenosine A3 receptor antagonists: inhibition of A3-mediated human glioblastoma cell proliferation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 9.82 | 10.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1098108 | — | — | 1 | 10.24 |
| CHEMBL1096754 | — | — | 1 | 9.39 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1098108 | — | IC50 | = | 0.057 | nM | 10.24 |
| CHEMBL1096754 | — | IC50 | = | 0.41 | nM | 9.39 |