Assay Detail
Binding
CHEMBL1120811
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Binding affinity to ERbeta by fluorescence polarization-based competitive binding assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis and evaluation of 17alpha-arylestradiols as ligands for estrogen receptor alpha and beta.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.93 | 7.95 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL135 | ESTRADIOL | 4.0 | 1 | 7.95 |
| CHEMBL691 | ETHINYL ESTRADIOL | 4.0 | 1 | 7.75 |
| CHEMBL1098710 | — | — | 1 | 7.27 |
| CHEMBL1097377 | — | — | 1 | 7.12 |
| CHEMBL1094732 | — | — | 1 | 6.60 |
| CHEMBL1098709 | — | — | 1 | 6.50 |
| CHEMBL1097284 | — | — | 1 | 6.30 |
| CHEMBL1096975 | — | — | 1 | 5.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL135 | ESTRADIOL | IC50 | = | 11.35 | nM | 7.95 |
| CHEMBL691 | ETHINYL ESTRADIOL | IC50 | = | 17.78 | nM | 7.75 |
| CHEMBL1098710 | — | IC50 | = | 53.58 | nM | 7.27 |
| CHEMBL1097377 | — | IC50 | = | 76.38 | nM | 7.12 |
| CHEMBL1094732 | — | IC50 | = | 253.51 | nM | 6.60 |
| CHEMBL1098709 | — | IC50 | = | 319.15 | nM | 6.50 |
| CHEMBL1097284 | — | IC50 | = | 500.03 | nM | 6.30 |
| CHEMBL1096975 | — | IC50 | = | 1083.93 | nM | 5.96 |