Assay Detail
Binding
CHEMBL1120815
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Transactivation of human ERbeta expressed in HEK293 cells after 18 hrs by luciferase reporter gene assay
9
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and evaluation of 17alpha-arylestradiols as ligands for estrogen receptor alpha and beta.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 9 | 7.48 | 10.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL135 | ESTRADIOL | 4.0 | 1 | 10.21 |
| CHEMBL1098710 | — | — | 2 | 7.64 |
| CHEMBL1097377 | — | — | 1 | 7.57 |
| CHEMBL1098709 | — | — | 1 | 7.46 |
| CHEMBL1096975 | — | — | 2 | 6.76 |
| CHEMBL1094732 | — | — | 1 | 6.66 |
| CHEMBL1097284 | — | — | 1 | 6.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL135 | ESTRADIOL | EC50 | = | 0.06166 | nM | 10.21 |
| CHEMBL1098710 | — | EC50 | = | 22.7 | nM | 7.64 |
| CHEMBL1098710 | — | EC50 | = | 22.65 | nM | 7.64 |
| CHEMBL1097377 | — | EC50 | = | 26.67 | nM | 7.57 |
| CHEMBL1098709 | — | EC50 | = | 34.59 | nM | 7.46 |
| CHEMBL1096975 | — | EC50 | = | 175.39 | nM | 6.76 |
| CHEMBL1096975 | — | EC50 | = | 174.0 | nM | 6.76 |
| CHEMBL1094732 | — | EC50 | = | 221.31 | nM | 6.66 |
| CHEMBL1097284 | — | EC50 | = | 242.1 | nM | 6.62 |