Assay Detail
Functional
CHEMBL1121040
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Cytotoxicity against human CRL2365 cells by MTT assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and evaluation of verticipyrone analogues as mitochondrial complex I inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.13 | 5.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1097830 | — | — | 1 | 5.62 |
| CHEMBL1097829 | — | — | 1 | 5.48 |
| CHEMBL1098149 | — | — | 1 | 4.91 |
| CHEMBL1097844 | — | — | 1 | 4.52 |
| CHEMBL1097845 | — | — | 1 | - |
| CHEMBL1097846 | — | — | 1 | - |
| CHEMBL1096106 | — | — | 1 | - |
| CHEMBL1097831 | — | — | 1 | - |
| CHEMBL1097513 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1097830 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL1097829 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL1098149 | — | IC50 | = | 12400.0 | nM | 4.91 |
| CHEMBL1097844 | — | IC50 | = | 29900.0 | nM | 4.52 |
| CHEMBL1097845 | — | IC50 | > | 31000.0 | nM | - |
| CHEMBL1097846 | — | IC50 | > | 31000.0 | nM | - |
| CHEMBL1096106 | — | IC50 | > | 31000.0 | nM | - |
| CHEMBL1097831 | — | IC50 | > | 31000.0 | nM | - |
| CHEMBL1097513 | — | IC50 | > | 27000.0 | nM | - |