Assay Detail
Binding
CHEMBL1166366
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Inhibition of Bacillus thermoproteolyticus thermolysin after 15 mins by microplate fluorescence analysis in presence of 0.1 M substrate FaGLa
37
Total Activities
37
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bacillus thermoproteolyticus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Identification of novel quinazolin-4(3H)-ones as inhibitors of thermolysin, the prototype of the M4 family of proteinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 37 | 5.37 | 7.94 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1164452 | — | — | 1 | 7.94 |
| CHEMBL1163762 | — | — | 1 | 6.61 |
| CHEMBL1163173 | — | — | 1 | 5.90 |
| CHEMBL1163157 | — | — | 1 | 4.42 |
| CHEMBL1163745 | — | — | 1 | 4.38 |
| CHEMBL1163152 | — | — | 1 | 4.26 |
| CHEMBL1164862 | — | — | 1 | 4.11 |
| CHEMBL1163763 | — | — | 1 | - |
| CHEMBL1164655 | — | — | 1 | - |
| CHEMBL1164451 | — | — | 1 | - |
| CHEMBL1163171 | — | — | 1 | - |
| CHEMBL1165641 | — | — | 1 | - |
| CHEMBL1164444 | — | — | 1 | - |
| CHEMBL1163224 | — | — | 1 | - |
| CHEMBL1163487 | — | — | 1 | - |
| CHEMBL1163483 | — | — | 1 | - |
| CHEMBL1163168 | — | — | 1 | - |
| CHEMBL1163482 | — | — | 1 | - |
| CHEMBL1164448 | — | — | 1 | - |
| CHEMBL1164161 | — | — | 1 | - |
| CHEMBL1164165 | — | — | 1 | - |
| CHEMBL1164078 | — | — | 1 | - |
| CHEMBL1163684 | — | — | 1 | - |
| CHEMBL1163169 | — | — | 1 | - |
| CHEMBL1163683 | — | — | 1 | - |
| CHEMBL1163633 | — | — | 1 | - |
| CHEMBL1163632 | — | — | 1 | - |
| CHEMBL1164450 | — | — | 1 | - |
| CHEMBL1163963 | — | — | 1 | - |
| CHEMBL1163744 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1164452 | — | IC50 | = | 11.5 | nM | 7.94 |
| CHEMBL1163762 | — | IC50 | = | 247.7 | nM | 6.61 |
| CHEMBL1163173 | — | IC50 | = | 1250.0 | nM | 5.90 |
| CHEMBL1163157 | — | IC50 | = | 37860.0 | nM | 4.42 |
| CHEMBL1163745 | — | IC50 | = | 42030.0 | nM | 4.38 |
| CHEMBL1163152 | — | IC50 | = | 54890.0 | nM | 4.26 |
| CHEMBL1164862 | — | IC50 | = | 76850.0 | nM | 4.11 |
| CHEMBL1165641 | — | IC50 | - | — | - | |
| CHEMBL1163167 | — | IC50 | - | — | - | |
| CHEMBL1164444 | — | IC50 | - | — | - | |
| CHEMBL1163224 | — | IC50 | - | — | - | |
| CHEMBL1163487 | — | IC50 | - | — | - | |
| CHEMBL1163483 | — | IC50 | - | — | - | |
| CHEMBL1163168 | — | IC50 | - | — | - | |
| CHEMBL1163482 | — | IC50 | - | — | - | |
| CHEMBL1164655 | — | IC50 | = | 12743000.0 | nM | - |
| CHEMBL1164912 | — | IC50 | - | — | - | |
| CHEMBL1164475 | — | IC50 | - | — | - | |
| CHEMBL1165543 | — | IC50 | - | — | - | |
| CHEMBL1164981 | — | IC50 | - | — | - | |
| CHEMBL1164980 | — | IC50 | = | 3118000.0 | nM | - |
| CHEMBL1164861 | — | IC50 | - | — | - | |
| CHEMBL1163171 | — | IC50 | - | — | - | |
| CHEMBL1164451 | — | IC50 | - | — | - | |
| CHEMBL1163763 | — | IC50 | - | — | - | |
| CHEMBL1164448 | — | IC50 | - | — | - | |
| CHEMBL1164161 | — | IC50 | - | — | - | |
| CHEMBL1164165 | — | IC50 | - | — | - | |
| CHEMBL1164078 | — | IC50 | - | — | - | |
| CHEMBL1163684 | — | IC50 | = | 122637.0 | nM | - |
| CHEMBL1163169 | — | IC50 | - | — | - | |
| CHEMBL1163683 | — | IC50 | - | — | - | |
| CHEMBL1163633 | — | IC50 | - | — | - | |
| CHEMBL1163632 | — | IC50 | = | 4002000.0 | nM | - |
| CHEMBL1164450 | — | IC50 | = | 1832000.0 | nM | - |
| CHEMBL1163963 | — | IC50 | - | — | - | |
| CHEMBL1163744 | — | IC50 | - | — | - |