Assay Detail
Binding
CHEMBL1167749
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of esterase activity of human carbonic anhydrase 2 by spectrophotometry
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
A novel and one-pot synthesis of new 1-tosyl pyrrol-2-one derivatives and analysis of carbonic anhydrase inhibitory potencies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.73 | 6.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1163554 | — | — | 1 | 6.68 |
| CHEMBL1164744 | — | — | 1 | 6.43 |
| CHEMBL1163131 | — | — | 1 | 4.95 |
| CHEMBL508732 | — | — | 1 | 4.84 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1163554 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL1164744 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL1163131 | — | IC50 | = | 11240.0 | nM | 4.95 |
| CHEMBL508732 | — | IC50 | = | 14290.0 | nM | 4.84 |