Assay Detail
Binding
CHEMBL1167751
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Inhibition of esterase activity of human carbonic anhydrase 2 by Lineweaver-Burke plot analysis
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
A novel and one-pot synthesis of new 1-tosyl pyrrol-2-one derivatives and analysis of carbonic anhydrase inhibitory potencies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 5.59 | 6.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 6.43 |
| CHEMBL1163554 | — | — | 1 | 6.29 |
| CHEMBL1164744 | — | — | 1 | 6.14 |
| CHEMBL1163131 | — | — | 1 | 4.64 |
| CHEMBL508732 | — | — | 1 | 4.43 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 370.0 | nM | 6.43 |
| CHEMBL1163554 | — | Ki | = | 510.0 | nM | 6.29 |
| CHEMBL1164744 | — | Ki | = | 730.0 | nM | 6.14 |
| CHEMBL1163131 | — | Ki | = | 23100.0 | nM | 4.64 |
| CHEMBL508732 | — | Ki | = | 37500.0 | nM | 4.43 |