Assay Detail
Binding
CHEMBL1167758
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Mycobacterium tuberculosis PTPA-mediated pNPP hydrolysis
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mycobacterium tuberculosis |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Low molecular weight protein-tyrosine phosphatase A (CHEMBL4542) ↗| Type | SINGLE PROTEIN |
| Organism | Mycobacterium tuberculosis |
Publication
Inhibition of Mycobacterium tuberculosis tyrosine phosphatase PtpA by synthetic chalcones: kinetics, molecular modeling, toxicity and effect on growth.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 5.01 | 5.31 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL217931 | — | — | 1 | 5.31 |
| CHEMBL441861 | — | — | 1 | 5.27 |
| CHEMBL487051 | — | — | 1 | 5.04 |
| CHEMBL484145 | — | — | 1 | 4.75 |
| CHEMBL374279 | — | — | 1 | 4.67 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL217931 | — | Ki | = | 4900.0 | nM | 5.31 |
| CHEMBL441861 | — | Ki | = | 5400.0 | nM | 5.27 |
| CHEMBL487051 | — | Ki | = | 9100.0 | nM | 5.04 |
| CHEMBL484145 | — | Ki | = | 17900.0 | nM | 4.75 |
| CHEMBL374279 | — | Ki | = | 21300.0 | nM | 4.67 |