Assay Detail
Functional
CHEMBL1167905
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Inhibition of rat RBL2H3 cell granulation assessed as reduction of beta hexasaminidase release
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | RBL-2H3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Computational screening for membrane-directed inhibitors of mast cell activation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.26 | 5.36 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL570362 | — | — | 1 | 5.36 |
| CHEMBL125 | MILTEFOSINE | 4.0 | 1 | 5.34 |
| CHEMBL372764 | PERIFOSINE | 3.0 | 1 | 5.30 |
| CHEMBL1163447 | — | — | 1 | 5.26 |
| CHEMBL1164924 | — | — | 1 | 5.24 |
| CHEMBL28930 | ILMOFOSINE | 2.0 | 1 | 5.19 |
| CHEMBL107514 | (R)-EDELFOSINE | — | 1 | 5.15 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL570362 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL125 | MILTEFOSINE | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL372764 | PERIFOSINE | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL1163447 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL1164924 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL28930 | ILMOFOSINE | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL107514 | (R)-EDELFOSINE | IC50 | = | 7100.0 | nM | 5.15 |