Compound Detail
CHEMBL372764
PERIFOSINE 🧪 Phase III
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🧪 Phase III
Basic Information
| ChEMBL ID | CHEMBL372764 |
| Name | PERIFOSINE |
| Phase | Phase III |
| Structure Type | MOL |
| InChI Key | SZFPYBIJACMNJV-UHFFFAOYSA-N |
11
Targets
35
Activities
2
Assay Types
0
PK Parameters
20
Publications
5
Known Names
20
Indications
Molecular Properties
461.7
MW (Da)
6.99
ALogP
4
HBA
0
HBD
58.6
PSA (Ų)
0.11
QED
1
Ro5 Violations
20
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Racemic |
Indications
Colorectal Neoplasms Multiple Myeloma Breast Neoplasms Carcinoma, Renal Cell Colonic Neoplasms Gastrointestinal Stromal Tumors Head and Neck Neoplasms Kidney Neoplasms Leukemia Leukemia, Lymphocytic, Chronic, B-Cell Lymphoma Melanoma Pancreatic Neoplasms Prostatic Neoplasms Prostatic Neoplasms, Castration-Resistant Sarcoma Waldenstrom Macroglobulinemia Astrocytoma Brain Neoplasms Carcinoma, Non-Small-Cell Lung
Activity Summary
IC50 34 meas. best 7.3
EC50 1 meas. best 5.52
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Ubiquitin carboxyl-terminal hydrolase isozyme L3 CHEMBL6195 | IC50 | 7.3 | 7.3 | 50.0 | 1 |
| Telomerase reverse transcriptase CHEMBL2916 | IC50 | 6.74 | 6.74 | 184.0 | 10 |
| Unchecked CHEMBL612545 | IC50 | 6.07 | 5.4863 | 851.9 | 8 |
| Mitogen-activated protein kinase 14 CHEMBL260 | IC50 | 5.92 | 5.92 | 1200.0 | 1 |
| Leishmania donovani CHEMBL367 | EC50 | 5.52 | 5.52 | 3020.0 | 1 |
| A549 CHEMBL392 | IC50 | 5.38 | 5.2333 | 4170.0 | 3 |
| Leishmania infantum CHEMBL612848 | IC50 | 5.38 | 5.0833 | 4200.0 | 3 |
| RBL-2H3 CHEMBL614632 | IC50 | 5.3 | 5.3 | 5000.0 | 1 |
| RAC-alpha serine/threonine-protein kinase CHEMBL4282 | IC50 | 5.28 | 4.82 | 5300.0 | 2 |
| NON-PROTEIN TARGET CHEMBL3879801 | IC50 | 4.89 | 4.89 | 12800.0 | 2 |
| MCF7 CHEMBL387 | IC50 | 4.88 | 4.6267 | 13300.0 | 3 |
Activity Data Samples
Top measurements by pChEMBL value
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 36669398 | 10.1016/j.ejmech.2023.115121 | Telomerase reverse transcriptase | 10 |
| 24900620 | 10.1021/ml400162g | A549 | 7 |
| 29191878 | 10.1126/science.aan4368 | Unchecked | 5 |
| 17908944 | 10.1128/aac.00465-07 | Leishmania donovani | 4 |
| 18644961 | 10.1128/aac.00587-08 | Leishmania infantum | 3 |
| 16190765 | 10.1021/jm050189v | ADMET | 3 |
| 20153565 | 10.1016/j.ejmech.2010.01.061 | RBL-2H3 | 2 |
| - | 10.6019/CHEMBL4808148 | Histone deacetylase 6 | 2 |
| - | 10.6019/CHEMBL4495565 | SARS-CoV-2 | 2 |
| 22138309 | 10.1016/j.ejmech.2011.11.018 | Unchecked | 2 |
| 21543141 | 10.1016/j.ejmech.2011.04.009 | NCI-H23 | 1 |
| 23266181 | 10.1016/j.bmc.2012.11.027 | ACHN | 1 |
| 23266181 | 10.1016/j.bmc.2012.11.027 | HCT-15 | 1 |
| 38295689 | 10.1016/j.ejmech.2023.116117 | Unchecked | 1 |
| 22138309 | 10.1016/j.ejmech.2011.11.018 | MCF7 | 1 |
| 22138309 | 10.1016/j.ejmech.2011.11.018 | A549 | 1 |
| 21543141 | 10.1016/j.ejmech.2011.04.009 | ACHN | 1 |
| 21543141 | 10.1016/j.ejmech.2011.04.009 | HCT-15 | 1 |
| 21543141 | 10.1016/j.ejmech.2011.04.009 | NUGC-3 | 1 |
| 20153565 | 10.1016/j.ejmech.2010.01.061 | ADMET | 1 |
Data from ChEMBL 36 via Core Engine