Assay Detail
Functional
CHEMBL3095847
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Cytotoxicity against human A549 cells after 24 to 72 hrs by haemocytometry
12
Total Activities
6
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis of Novel 3,5-Disubstituted-2-oxindole Derivatives As Antitumor Agents against Human Nonsmall Cell Lung Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Activity | 6 | - | - |
| IC50 | 6 | 5.38 | 6.18 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3091671 | — | — | 2 | 6.18 |
| CHEMBL3091673 | — | — | 2 | 5.66 |
| CHEMBL3091672 | — | — | 2 | 5.56 |
| CHEMBL372764 | PERIFOSINE | 3.0 | 2 | 5.38 |
| CHEMBL3091675 | — | — | 2 | 4.79 |
| CHEMBL3091674 | — | — | 2 | 4.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3091671 | — | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL3091673 | — | IC50 | = | 2190.0 | nM | 5.66 |
| CHEMBL3091672 | — | IC50 | = | 2750.0 | nM | 5.56 |
| CHEMBL372764 | PERIFOSINE | IC50 | = | 4170.0 | nM | 5.38 |
| CHEMBL3091675 | — | IC50 | = | 16220.0 | nM | 4.79 |
| CHEMBL3091674 | — | IC50 | = | 19950.0 | nM | 4.70 |
| CHEMBL372764 | PERIFOSINE | Activity | - | — | - | |
| CHEMBL3091675 | — | Activity | - | — | - | |
| CHEMBL3091674 | — | Activity | - | — | - | |
| CHEMBL3091673 | — | Activity | - | — | - | |
| CHEMBL3091672 | — | Activity | - | — | - | |
| CHEMBL3091671 | — | Activity | - | — | - |