Assay Detail
Binding
CHEMBL1168041
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human lysosome alpha-galactosidase assessed as p-nitrophenol release by spectrometric analysis
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
2,5-Dideoxy-2,5-imino-d-altritol as a new class of pharmacological chaperone for Fabry disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.64 | 7.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL110458 | MIGALASTAT | 4.0 | 1 | 7.16 |
| CHEMBL469844 | — | — | 1 | 6.16 |
| CHEMBL1163255 | — | — | 1 | 4.82 |
| CHEMBL1163562 | — | — | 1 | 4.41 |
| CHEMBL1163254 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL110458 | MIGALASTAT | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL469844 | — | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL1163255 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL1163562 | — | IC50 | = | 39000.0 | nM | 4.41 |
| CHEMBL1163254 | — | IC50 | = | 224000.0 | nM | - |