Assay Detail
Binding
CHEMBL1173891
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human MetAP1
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Subtype-selectivity of metal-dependent methionine aminopeptidase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 4.49 | 5.09 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL89671 | — | — | 1 | 5.09 |
| CHEMBL202826 | — | — | 1 | 4.99 |
| CHEMBL381945 | — | — | 1 | 4.72 |
| CHEMBL310555 | OXYQUINOLINE | -1.0 | 1 | 4.67 |
| CHEMBL371481 | — | — | 1 | 4.56 |
| CHEMBL72683 | — | — | 1 | 4.55 |
| CHEMBL380979 | — | — | 1 | 4.54 |
| CHEMBL371956 | — | — | 1 | 4.49 |
| CHEMBL352049 | — | — | 1 | 4.49 |
| CHEMBL372564 | — | — | 1 | 4.49 |
| CHEMBL371544 | — | — | 1 | 4.47 |
| CHEMBL199982 | — | — | 1 | 4.46 |
| CHEMBL199448 | — | — | 1 | 4.45 |
| CHEMBL199806 | — | — | 1 | 4.43 |
| CHEMBL203476 | — | — | 1 | 4.41 |
| CHEMBL201143 | — | — | 1 | 4.40 |
| CHEMBL1171506 | — | — | 1 | 4.40 |
| CHEMBL199461 | — | — | 1 | 4.39 |
| CHEMBL1169657 | — | — | 1 | 4.38 |
| CHEMBL1170610 | BENZOXIQUINE | 2.0 | 1 | 4.37 |
| CHEMBL257286 | — | — | 1 | 4.35 |
| CHEMBL370580 | — | — | 1 | 4.34 |
| CHEMBL370581 | — | — | 1 | 4.33 |
| CHEMBL625 | THIABENDAZOLE | 4.0 | 1 | 4.32 |
| CHEMBL370771 | — | — | 1 | 4.31 |
| CHEMBL166127 | — | — | 1 | 4.31 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL89671 | — | IC50 | = | 8100.0 | nM | 5.09 |
| CHEMBL202826 | — | IC50 | = | 10300.0 | nM | 4.99 |
| CHEMBL381945 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL310555 | OXYQUINOLINE | IC50 | = | 21500.0 | nM | 4.67 |
| CHEMBL371481 | — | IC50 | = | 27600.0 | nM | 4.56 |
| CHEMBL72683 | — | IC50 | = | 28400.0 | nM | 4.55 |
| CHEMBL380979 | — | IC50 | = | 28800.0 | nM | 4.54 |
| CHEMBL371956 | — | IC50 | = | 32600.0 | nM | 4.49 |
| CHEMBL352049 | — | IC50 | = | 32600.0 | nM | 4.49 |
| CHEMBL372564 | — | IC50 | = | 32400.0 | nM | 4.49 |
| CHEMBL371544 | — | IC50 | = | 33900.0 | nM | 4.47 |
| CHEMBL199982 | — | IC50 | = | 34700.0 | nM | 4.46 |
| CHEMBL199448 | — | IC50 | = | 35500.0 | nM | 4.45 |
| CHEMBL199806 | — | IC50 | = | 37300.0 | nM | 4.43 |
| CHEMBL203476 | — | IC50 | = | 38800.0 | nM | 4.41 |
| CHEMBL201143 | — | IC50 | = | 40100.0 | nM | 4.40 |
| CHEMBL1171506 | — | IC50 | = | 39800.0 | nM | 4.40 |
| CHEMBL199461 | — | IC50 | = | 41000.0 | nM | 4.39 |
| CHEMBL1169657 | — | IC50 | = | 41200.0 | nM | 4.38 |
| CHEMBL1170610 | BENZOXIQUINE | IC50 | = | 42800.0 | nM | 4.37 |
| CHEMBL257286 | — | IC50 | = | 44900.0 | nM | 4.35 |
| CHEMBL370580 | — | IC50 | = | 45800.0 | nM | 4.34 |
| CHEMBL370581 | — | IC50 | = | 47000.0 | nM | 4.33 |
| CHEMBL625 | THIABENDAZOLE | IC50 | = | 47800.0 | nM | 4.32 |
| CHEMBL370771 | — | IC50 | = | 48500.0 | nM | 4.31 |
| CHEMBL166127 | — | IC50 | = | 48800.0 | nM | 4.31 |