Compound Detail
CHEMBL370771
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Basic Information
| ChEMBL ID | CHEMBL370771 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | LPEUFGNVMRMLRM-UHFFFAOYSA-N |
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
7
Publications
0
Known Names
Molecular Properties
246.2
MW (Da)
2.59
ALogP
5
HBA
1
HBD
84.7
PSA (Ų)
0.56
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 5.92
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Unchecked CHEMBL612545 | IC50 | 5.92 | 5.92 | 1200.0 | 1 |
| Methionine aminopeptidase CHEMBL3423 | IC50 | 5.91 | 5.91 | 1218.0 | 1 |
| Methionine aminopeptidase 1 CHEMBL2474 | IC50 | 4.31 | 4.31 | 48500.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Unchecked | IC50 | = | 1200.0 | nM | 5.92 | Inhibition of Escherichia coli MetAP | 20621724 |
| Methionine aminopeptidase | IC50 | = | 1218.0 | nM | 5.91 | Inhibition of Co2+ loaded MetAP expressed in Escherichia coli | 16420038 |
| Methionine aminopeptidase 1 | IC50 | = | 48500.0 | nM | 4.31 | Inhibition of human MetAP1 | 20621724 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 16420038 | 10.1021/jm050476z | Methionine aminopeptidase | 2 |
| 20621724 | 10.1016/j.bmcl.2010.05.093 | Unchecked | 2 |
| 20621724 | 10.1016/j.bmcl.2010.05.093 | Methionine aminopeptidase 1 | 2 |
| 25936258 | 10.1016/j.bmc.2015.03.085 | HUVEC | 2 |
| 20621724 | 10.1016/j.bmcl.2010.05.093 | Methionine aminopeptidase 2 | 1 |
| 31699536 | 10.1016/j.ejmech.2019.111822 | NACHT, LRR and PYD domains-containing protein 3 | 1 |
| 37573828 | 10.1016/j.ejmech.2023.115718 | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine