Assay Detail
Binding
CHEMBL865844
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Inhibition of Co2+ loaded MetAP expressed in Escherichia coli
41
Total Activities
41
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Escherichia coli |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Metal-mediated inhibition of Escherichia coli methionine aminopeptidase: structure-activity relationships and development of a novel scoring function for metal-ligand interactions.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 41 | 5.98 | 7.11 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL197704 | — | — | 1 | 7.11 |
| CHEMBL371481 | — | — | 1 | 6.98 |
| CHEMBL380979 | — | — | 1 | 6.79 |
| CHEMBL201143 | — | — | 1 | 6.62 |
| CHEMBL371544 | — | — | 1 | 6.42 |
| CHEMBL199753 | — | — | 1 | 6.39 |
| CHEMBL199806 | — | — | 1 | 6.37 |
| CHEMBL200115 | — | — | 1 | 6.34 |
| CHEMBL625 | THIABENDAZOLE | 4.0 | 1 | 6.33 |
| CHEMBL372564 | — | — | 1 | 6.30 |
| CHEMBL378360 | — | — | 1 | 6.27 |
| CHEMBL202826 | — | — | 1 | 6.26 |
| CHEMBL72683 | — | — | 1 | 6.24 |
| CHEMBL372398 | — | — | 1 | 6.11 |
| CHEMBL199925 | — | — | 1 | 6.01 |
| CHEMBL373247 | — | — | 1 | 6.00 |
| CHEMBL370771 | — | — | 1 | 5.91 |
| CHEMBL164856 | — | — | 1 | 5.87 |
| CHEMBL199982 | — | — | 1 | 5.82 |
| CHEMBL166127 | — | — | 1 | 5.77 |
| CHEMBL381945 | — | — | 1 | 5.76 |
| CHEMBL352049 | — | — | 1 | 5.68 |
| CHEMBL199461 | — | — | 1 | 5.62 |
| CHEMBL371956 | — | — | 1 | 5.61 |
| CHEMBL198342 | — | — | 1 | 5.58 |
| CHEMBL370420 | — | — | 1 | 5.47 |
| CHEMBL198341 | — | — | 1 | 5.41 |
| CHEMBL370580 | — | — | 1 | 5.37 |
| CHEMBL200059 | — | — | 1 | 5.34 |
| CHEMBL370581 | — | — | 1 | 5.29 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL197704 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL371481 | — | IC50 | = | 105.0 | nM | 6.98 |
| CHEMBL380979 | — | IC50 | = | 162.0 | nM | 6.79 |
| CHEMBL201143 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL371544 | — | IC50 | = | 376.0 | nM | 6.42 |
| CHEMBL199753 | — | IC50 | = | 403.0 | nM | 6.39 |
| CHEMBL199806 | — | IC50 | = | 431.0 | nM | 6.37 |
| CHEMBL200115 | — | IC50 | = | 461.0 | nM | 6.34 |
| CHEMBL625 | THIABENDAZOLE | IC50 | = | 472.0 | nM | 6.33 |
| CHEMBL372564 | — | IC50 | = | 497.0 | nM | 6.30 |
| CHEMBL378360 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL202826 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL72683 | — | IC50 | = | 574.0 | nM | 6.24 |
| CHEMBL372398 | — | IC50 | = | 777.0 | nM | 6.11 |
| CHEMBL199925 | — | IC50 | = | 967.0 | nM | 6.01 |
| CHEMBL373247 | — | IC50 | = | 992.0 | nM | 6.00 |
| CHEMBL370771 | — | IC50 | = | 1218.0 | nM | 5.91 |
| CHEMBL164856 | — | IC50 | = | 1343.0 | nM | 5.87 |
| CHEMBL199982 | — | IC50 | = | 1511.0 | nM | 5.82 |
| CHEMBL166127 | — | IC50 | = | 1695.0 | nM | 5.77 |
| CHEMBL381945 | — | IC50 | = | 1724.0 | nM | 5.76 |
| CHEMBL352049 | — | IC50 | = | 2086.0 | nM | 5.68 |
| CHEMBL199461 | — | IC50 | = | 2397.0 | nM | 5.62 |
| CHEMBL371956 | — | IC50 | = | 2433.0 | nM | 5.61 |
| CHEMBL198342 | — | IC50 | = | 2598.0 | nM | 5.58 |
| CHEMBL370420 | — | IC50 | = | 3390.0 | nM | 5.47 |
| CHEMBL198341 | — | IC50 | = | 3906.0 | nM | 5.41 |
| CHEMBL370580 | — | IC50 | = | 4307.0 | nM | 5.37 |
| CHEMBL200059 | — | IC50 | = | 4591.0 | nM | 5.34 |
| CHEMBL370581 | — | IC50 | = | 5153.0 | nM | 5.29 |
| CHEMBL199448 | — | IC50 | = | 7157.0 | nM | 5.14 |
| CHEMBL382235 | — | IC50 | = | 8956.0 | nM | 5.05 |
| CHEMBL201221 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL83103 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL201094 | FUBERIDAZOLE | IC50 | > | 10000.0 | nM | - |
| CHEMBL70971 | CARBENDAZIM | IC50 | > | 10000.0 | nM | - |
| CHEMBL203360 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL37161 | FENBENDAZOLE | IC50 | > | 10000.0 | nM | - |
| CHEMBL1483 | ALBENDAZOLE | IC50 | > | 10000.0 | nM | - |
| CHEMBL685 | MEBENDAZOLE | IC50 | > | 10000.0 | nM | - |
| CHEMBL203476 | — | IC50 | > | 10000.0 | nM | - |