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Assay Detail

CHEMBL1173896

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antimalarial activity Plasmodium falciparum 3D7
45
Total Activities
45
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Plasmodium falciparum
Confidence 1 — Organism
Curated By Autocuration

Target

Plasmodium falciparum (CHEMBL364)
Type ORGANISM
Organism Plasmodium falciparum

Publication

Discovery of novel 1H-imidazol-2-yl-pyrimidine-4,6-diamines as potential antimalarials.
Deng X, Nagle A, Wu T, Sakata T, Henson K, Chen Z, Kuhen K, Plouffe D, Winzeler E, Adrian F, Tuntland T, Chang J, Simerson S, Howard S, Ek J, Isbell J, Tully DC, Chatterjee AK, Gray NS.
Bioorg Med Chem Lett (2010) 20 : 4027 -4031
PubMed 20610151 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 45 6.73 8.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL269671 ARTEMISININ 3.0 1 8.00
CHEMBL416956 MEFLOQUINE 4.0 1 7.70
CHEMBL1539 SULFADOXINE 4.0 1 7.52
CHEMBL1170107 1 7.47
CHEMBL1172156 1 7.34
CHEMBL1171893 1 7.31
CHEMBL1170108 1 7.28
CHEMBL1172664 1 7.27
CHEMBL1172433 1 7.22
CHEMBL1170121 1 7.22
CHEMBL1172029 1 7.19
CHEMBL1171514 1 7.17
CHEMBL1172434 1 7.16
CHEMBL1170200 1 7.13
CHEMBL1172034 1 7.06
CHEMBL1172031 1 7.06
CHEMBL1172032 1 7.05
CHEMBL1172033 1 7.04
CHEMBL1172430 1 7.04
CHEMBL1170384 1 6.97
CHEMBL1171785 1 6.95
CHEMBL1169911 1 6.94
CHEMBL1171964 1 6.94
CHEMBL1172435 1 6.78
CHEMBL1172030 1 6.76
CHEMBL1170120 1 6.72
CHEMBL1170823 1 6.65
CHEMBL1172436 1 6.65
CHEMBL1172437 1 6.62
CHEMBL1172431 1 6.60

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL269671 ARTEMISININ EC50 = 10.0 nM 8.00
CHEMBL416956 MEFLOQUINE EC50 = 20.0 nM 7.70
CHEMBL1539 SULFADOXINE EC50 = 30.0 nM 7.52
CHEMBL1170107 EC50 = 34.0 nM 7.47
CHEMBL1172156 EC50 = 46.0 nM 7.34
CHEMBL1171893 EC50 = 49.0 nM 7.31
CHEMBL1170108 EC50 = 53.0 nM 7.28
CHEMBL1172664 EC50 = 54.0 nM 7.27
CHEMBL1172433 EC50 = 60.0 nM 7.22
CHEMBL1170121 EC50 = 60.0 nM 7.22
CHEMBL1172029 EC50 = 65.0 nM 7.19
CHEMBL1171514 EC50 = 67.0 nM 7.17
CHEMBL1172434 EC50 = 69.0 nM 7.16
CHEMBL1170200 EC50 = 74.0 nM 7.13
CHEMBL1172031 EC50 = 88.0 nM 7.06
CHEMBL1172034 EC50 = 87.0 nM 7.06
CHEMBL1172032 EC50 = 90.0 nM 7.05
CHEMBL1172033 EC50 = 92.0 nM 7.04
CHEMBL1172430 EC50 = 91.0 nM 7.04
CHEMBL1170384 EC50 = 107.0 nM 6.97
CHEMBL1171785 EC50 = 113.0 nM 6.95
CHEMBL1171964 EC50 = 114.0 nM 6.94
CHEMBL1169911 EC50 = 116.0 nM 6.94
CHEMBL1172435 EC50 = 168.0 nM 6.78
CHEMBL1172030 EC50 = 175.0 nM 6.76
CHEMBL1170120 EC50 = 190.0 nM 6.72
CHEMBL1170823 EC50 = 223.0 nM 6.65
CHEMBL1172436 EC50 = 224.0 nM 6.65
CHEMBL1172437 EC50 = 239.0 nM 6.62
CHEMBL1172431 EC50 = 249.0 nM 6.60
CHEMBL1172538 EC50 = 268.0 nM 6.57
CHEMBL1169923 EC50 = 291.0 nM 6.54
CHEMBL1170199 EC50 = 353.0 nM 6.45
CHEMBL1171684 EC50 = 432.0 nM 6.37
CHEMBL1170822 EC50 = 436.0 nM 6.36
CHEMBL1169648 EC50 = 532.0 nM 6.27
CHEMBL1172539 EC50 = 564.0 nM 6.25
CHEMBL1172432 EC50 = 768.0 nM 6.12
CHEMBL1169818 EC50 = 822.0 nM 6.08
CHEMBL1171861 EC50 = 1330.0 nM 5.88
CHEMBL1169650 EC50 = 1777.0 nM 5.75
CHEMBL1170002 EC50 = 3830.0 nM 5.42
CHEMBL1172540 EC50 = 4240.0 nM 5.37
CHEMBL1169817 EC50 = 4680.0 nM 5.33
CHEMBL1170943 EC50 = 5440.0 nM 5.26