Assay Detail
Binding
CHEMBL1174254
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of N-terminal 6His-tagged human aldose reductase expressed in Escherichia coli BL21(DE3) mediated NADPH linked pyridine-3-aldehyde reduction
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Aldo-keto reductase family 1 member B1 (CHEMBL1900) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Chromene-3-carboxamide derivatives discovered from virtual screening as potent inhibitors of the tumour maker, AKR1B10.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 7.48 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL436 | TOLRESTAT | 4.0 | 1 | 8.00 |
| CHEMBL1172665 | — | — | 1 | 7.96 |
| CHEMBL1171546 | — | — | 1 | 7.68 |
| CHEMBL56337 | EPALRESTAT | 4.0 | 1 | 7.68 |
| CHEMBL273910 | MINALRESTAT | 2.0 | 1 | 7.60 |
| CHEMBL1169757 | — | — | 1 | 7.47 |
| CHEMBL1169756 | — | — | 1 | 7.44 |
| CHEMBL10372 | ZOPOLRESTAT | 2.0 | 1 | 7.22 |
| CHEMBL266497 | SORBINIL | 3.0 | 1 | 6.26 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL436 | TOLRESTAT | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL1172665 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL1171546 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL56337 | EPALRESTAT | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL273910 | MINALRESTAT | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL1169757 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL1169756 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL10372 | ZOPOLRESTAT | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL266497 | SORBINIL | IC50 | = | 550.0 | nM | 6.26 |