Assay Detail
Functional
CHEMBL1174294
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Antiinflammatory activity in human neutrophils assessed as inhibition of FMLP-induced superoxide anion generation treated 5 mins before FMLP challenge measured after 10 mins by spectrophotometer analysis
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Neutrophil |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and evaluation of benzoxazinone derivatives on activity of human neutrophil elastase and on hemorrhagic shock-induced lung injury in rats.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 5.15 | 6.01 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL365739 | DIPHENYLENEIODONIUM | — | 1 | 6.01 |
| CHEMBL1172107 | — | — | 1 | 5.92 |
| CHEMBL1172257 | — | — | 1 | 5.86 |
| CHEMBL1172673 | — | — | 1 | 5.70 |
| CHEMBL1172672 | — | — | 1 | 5.57 |
| CHEMBL1172307 | — | — | 1 | 5.19 |
| CHEMBL190610 | — | — | 1 | 5.18 |
| CHEMBL189686 | — | — | 1 | 5.06 |
| CHEMBL190204 | — | — | 1 | 5.00 |
| CHEMBL363193 | — | — | 1 | 4.76 |
| CHEMBL1172305 | — | — | 1 | 4.63 |
| CHEMBL190133 | — | — | 1 | 4.60 |
| CHEMBL1172265 | — | — | 1 | 4.60 |
| CHEMBL1172443 | — | — | 1 | 4.60 |
| CHEMBL1172306 | — | — | 1 | 4.60 |
| CHEMBL1172108 | ELASTATINAL | — | 1 | - |
| CHEMBL190503 | PHENYLMETHYLSULFONYLFLUORIDE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL365739 | DIPHENYLENEIODONIUM | IC50 | = | 969.7 | nM | 6.01 |
| CHEMBL1172107 | — | IC50 | = | 1206.1 | nM | 5.92 |
| CHEMBL1172257 | — | IC50 | = | 1381.8 | nM | 5.86 |
| CHEMBL1172673 | — | IC50 | = | 2002.1 | nM | 5.70 |
| CHEMBL1172672 | — | IC50 | = | 2680.5 | nM | 5.57 |
| CHEMBL1172307 | — | IC50 | = | 6475.5 | nM | 5.19 |
| CHEMBL190610 | — | IC50 | = | 6560.0 | nM | 5.18 |
| CHEMBL189686 | — | IC50 | = | 8660.0 | nM | 5.06 |
| CHEMBL190204 | — | IC50 | = | 10030.0 | nM | 5.00 |
| CHEMBL363193 | — | IC50 | = | 17490.0 | nM | 4.76 |
| CHEMBL1172305 | — | IC50 | = | 23393.8 | nM | 4.63 |
| CHEMBL190133 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL1172265 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL1172443 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL1172306 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL1172108 | ELASTATINAL | IC50 | - | — | - | |
| CHEMBL190503 | PHENYLMETHYLSULFONYLFLUORIDE | IC50 | - | — | - |