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Assay Detail

CHEMBL1175304

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Binding
Binding affinity to Influenza A Weybridge(H7N7) virus Matrix protein 2 by spectrophotometry
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Influenza A virus (A/chicken/FPV/Weybridge(H7N7))
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Matrix protein 2 (CHEMBL1932894)
Type SINGLE PROTEIN
Organism Influenza A virus

Publication

Interaction of aminoadamantane derivatives with the influenza A virus M2 channel-docking using a pore blocking model.
Eleftheratos S, Spearpoint P, Ortore G, Kolocouris A, Martinelli A, Martin S, Hay A.
Bioorg Med Chem Lett (2010) 20 : 4182 -4187
PubMed 20570509 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Kd 18 5.78 7.80

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL959 RIMANTADINE 4.0 1 7.80
CHEMBL660 AMANTADINE 4.0 1 6.50
CHEMBL323842 1 6.41
CHEMBL323901 1 6.29
CHEMBL295380 1 5.94
CHEMBL1172240 1 5.83
CHEMBL45179 1 5.82
CHEMBL294443 1 5.82
CHEMBL1170791 CYCLOOCTANAMINE 1 5.74
CHEMBL1170792 1 5.63
CHEMBL45505 1 5.53
CHEMBL1172027 1 5.44
CHEMBL1170180 1 5.31
CHEMBL1171000 1 5.25
CHEMBL1170181 1 5.17
CHEMBL1170182 1 5.06
CHEMBL1171864 CYCLOHEPTANAMINE 1 4.79
CHEMBL1171859 CYCLOPENTANAMINE 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL959 RIMANTADINE Kd = 16.0 nM 7.80
CHEMBL660 AMANTADINE Kd = 320.0 nM 6.50
CHEMBL323842 Kd = 390.0 nM 6.41
CHEMBL323901 Kd = 510.0 nM 6.29
CHEMBL295380 Kd = 1160.0 nM 5.94
CHEMBL1172240 Kd = 1490.0 nM 5.83
CHEMBL45179 Kd = 1500.0 nM 5.82
CHEMBL294443 Kd = 1510.0 nM 5.82
CHEMBL1170791 CYCLOOCTANAMINE Kd = 1830.0 nM 5.74
CHEMBL1170792 Kd = 2360.0 nM 5.63
CHEMBL45505 Kd = 2930.0 nM 5.53
CHEMBL1172027 Kd = 3600.0 nM 5.44
CHEMBL1170180 Kd = 4860.0 nM 5.31
CHEMBL1171000 Kd = 5580.0 nM 5.25
CHEMBL1170181 Kd = 6700.0 nM 5.17
CHEMBL1170182 Kd = 8710.0 nM 5.06
CHEMBL1171864 CYCLOHEPTANAMINE Kd = 16200.0 nM 4.79
CHEMBL1171859 CYCLOPENTANAMINE Kd - -