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Target Snapshot

CHEMBL1932894 Target Snapshot

Matrix protein 2 · SINGLE PROTEIN · Influenza A virus

Back to Search Search this target Browse approvals Evidence Card
129Compounds
33Assays
3Approved Drugs
93.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Matrix protein 2 shows approved-linked disease relevance led by influenza. 5 more disease programs remain visible in the same review block. 2 linked drugs keep the current disease frame grounded. Protein identity stays anchored to UniProt P06821. Start with influenza, then reuse UniProt P06821 as the stable protein anchor across project notes and exports.

Review focus
Review-ready target frame

Start with influenza, then reuse UniProt P06821 as the stable protein anchor across project notes and exports.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13 2 linked drugs
Open source guide
Disease program
influenza

Matrix protein 2 shows approved-linked disease relevance led by influenza. 5 more disease programs remain visible in the same review block. 2 linked drugs remain visible in the same block.

Start review with influenza because it currently carries approved-linked support. Linked drugs include AMANTADINE HYDROCHLORIDE, TCN-032. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

Disease source · ChEMBL drug mechanism + indication proxy
Approved-linked Open Targets-ready proxy 2 linked drugs
Open disease block
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Matrix protein 2 as ChEMBL target CHEMBL1932894, mapped to UniProt P06821. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Matrix protein 2
SINGLE PROTEIN · Influenza A virus
As of 2026-09-13
ChEMBL target ID
CHEMBL1932894
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
P06821
Matrix protein 2
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Matrix protein 2 is the right protein anchor across sources, using UniProt P06821 as the stable mapping.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need to confirm why influenza is currently framed as approved-linked support. It currently carries 2 linked drugs in the same disease frame.

Jump to Disease Context
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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameMatrix protein 2
Target TypeSINGLE PROTEIN
OrganismInfluenza A virus
UniProtP06821
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelMatrix protein 2
UniProt AccessionP06821
Component TypeProtein
Sequence Length97 aa

Matrix protein 2

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Matrix protein 2, mapped to UniProt P06821. Sequence length is 97 aa.

Mapped IDP06821
Review nameMatrix protein 2
OrganismInfluenza A virus
Disease Relevance

Disease Relevance & Evidence Level

Open Targets-ready disease context using the current target-indication evidence contract.

Approved-linked Open Targets-ready proxy

Matrix protein 2 shows approved-linked disease relevance led by influenza. 5 more disease programs remain visible in the same review block.

Approved-linked Approved
influenza
2 linked drugs · 2 direct · 2 efficacy
Linked drugAMANTADINE HYDROCHLORIDE
Linked drugTCN-032
Approved-linked Approved
cerebral atherosclerosis
1 linked drug · 1 direct · 1 efficacy
Linked drugAMANTADINE HYDROCHLORIDE
Approved-linked Approved
infection
1 linked drug · 1 direct · 1 efficacy
Linked drugAMANTADINE HYDROCHLORIDE
Approved-linked Approved
Parkinson disease
1 linked drug · 1 direct · 1 efficacy
Linked drugAMANTADINE HYDROCHLORIDE
Approved-linked Approved
Parkinsonism
1 linked drug · 1 direct · 1 efficacy
Linked drugAMANTADINE HYDROCHLORIDE
Approved-linked Approved
postencephalitic Parkinson disease
1 linked drug · 1 direct · 1 efficacy
Linked drugAMANTADINE HYDROCHLORIDE
Source · ChEMBL drug mechanism + indication proxy
ChEMBL target record ↗
Review Cue

How to read disease relevance

Start review with influenza because it currently carries approved-linked support. Linked drugs include AMANTADINE HYDROCHLORIDE, TCN-032. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

Lead diseaseinfluenza
Strongest levelApproved-linked
Block modeOpen Targets-ready proxy
Clinical Profile

Clinical Phase Distribution

3
Approved
Assay Mix

Activity Type Distribution

IC5063.0
EC507.0
KD23.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL959 7.8 Kd 16.0 Approved
CHEMBL4277543 6.89 Kd 130.0 Preclinical
CHEMBL2165491 6.52 IC50 300.0 Preclinical
CHEMBL1235691 6.5 Kd 320.0 Preclinical
CHEMBL660 6.5 Kd 320.0 Approved
CHEMBL3392935 6.47 Kd 340.0 Preclinical
CHEMBL323842 6.41 Kd 390.0 Preclinical
CHEMBL323901 6.29 Kd 510.0 Preclinical
CHEMBL3415952 6.1 IC50 800.0 Preclinical
CHEMBL2078948 6.05 IC50 900.0 Preclinical
Distribution

pChEMBL Value Distribution

19
5.0
20
5.5
6
6.0
4
6.5
0
7.0
1
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

RIMANTADINE
CHEMBL959
Approved 1993
Properties Compare Identifier
AMANTADINE
CHEMBL660
Approved 1968
Properties Compare Identifier
Assay Landscape

Assay Landscape

33
Total Assays
67
Tested Compounds
1
Assay Types
Binding — 33 assays, 67 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 22 30 5.0
single protein format 5 20 5.9
cell membrane format 4 9 5.5
assay format 2 8 5.8

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine