Compound Detail
CHEMBL2165491
SPIROAMANTADINE Enter ChEMBL ID:
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Basic Information
| ChEMBL ID | CHEMBL2165491 |
| Name | SPIROAMANTADINE |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | SWIQYYKGWFIKJQ-BTJKTKAUSA-N |
| Parent Compound | CHEMBL2219886 |
| Active Moiety | CHEMBL2219886 |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
205.3
MW (Da)
2.76
ALogP
1
HBA
0
HBD
3.2
PSA (Ų)
0.59
QED
0
Ro5 Violations
0
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 6.52
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Matrix protein 2 CHEMBL1932894 | IC50 | 6.52 | 6.52 | 300.0 | 1 |
| Influenza A virus CHEMBL613740 | IC50 | 6.0 | 6.0 | 1000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Matrix protein 2 | IC50 | = | 300.0 | nM | 6.52 | Inhibition of Influenza A virus Matrix protein 2 V27A mutant | 22612288 |
| Influenza A virus | IC50 | = | 1000.0 | nM | 6.0 | Antiviral activity against Influenza A virus containing Matrix protein 2 V27A mu... | 22612288 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 22612288 | 10.1021/jm300455c | Influenza A virus | 1 |
| 22612288 | 10.1021/jm300455c | Matrix protein 2 | 1 |
Data from ChEMBL 36 via Core Engine