Assay Detail
Functional
CHEMBL1175360
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Cytotoxicity against human HCT116 cells after 48 hrs by MTT assay
41
Total Activities
41
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design and synthesis of 1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazoles and pyrazolo[3,4-b]pyridines for Aurora-A kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 41 | 4.59 | 5.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1171583 | — | — | 1 | 5.40 |
| CHEMBL384575 | — | — | 1 | 4.89 |
| CHEMBL1171393 | — | — | 1 | 4.89 |
| CHEMBL1172509 | — | — | 1 | 4.84 |
| CHEMBL1170390 | — | — | 1 | 4.81 |
| CHEMBL1170170 | — | — | 1 | 4.71 |
| CHEMBL1170204 | — | — | 1 | 4.66 |
| CHEMBL1172508 | — | — | 1 | 4.64 |
| CHEMBL1170389 | — | — | 1 | 4.61 |
| CHEMBL1172324 | — | — | 1 | 4.59 |
| CHEMBL1172541 | — | — | 1 | 4.58 |
| CHEMBL1172327 | — | — | 1 | 4.50 |
| CHEMBL1171584 | — | — | 1 | 4.49 |
| CHEMBL1172325 | — | — | 1 | 4.46 |
| CHEMBL1170203 | — | — | 1 | 4.42 |
| CHEMBL1172323 | — | — | 1 | 4.40 |
| CHEMBL1170815 | — | — | 1 | 4.39 |
| CHEMBL1172326 | — | — | 1 | 4.36 |
| CHEMBL1170388 | — | — | 1 | 4.36 |
| CHEMBL1172542 | — | — | 1 | 4.35 |
| CHEMBL1170112 | — | — | 1 | 4.31 |
| CHEMBL1169918 | — | — | 1 | 4.29 |
| CHEMBL1170007 | — | — | 1 | - |
| CHEMBL1170020 | — | — | 1 | - |
| CHEMBL1170021 | — | — | 1 | - |
| CHEMBL1172499 | — | — | 1 | - |
| CHEMBL1171517 | — | — | 1 | - |
| CHEMBL1172701 | — | — | 1 | - |
| CHEMBL1172702 | — | — | 1 | - |
| CHEMBL1171937 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1171583 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL384575 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL1171393 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL1172509 | — | IC50 | = | 14290.0 | nM | 4.84 |
| CHEMBL1170390 | — | IC50 | = | 15630.0 | nM | 4.81 |
| CHEMBL1170170 | — | IC50 | = | 19310.0 | nM | 4.71 |
| CHEMBL1170204 | — | IC50 | = | 21880.0 | nM | 4.66 |
| CHEMBL1172508 | — | IC50 | = | 23020.0 | nM | 4.64 |
| CHEMBL1170389 | — | IC50 | = | 24850.0 | nM | 4.61 |
| CHEMBL1172324 | — | IC50 | = | 25490.0 | nM | 4.59 |
| CHEMBL1172541 | — | IC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL1172327 | — | IC50 | = | 31700.0 | nM | 4.50 |
| CHEMBL1171584 | — | IC50 | = | 32270.0 | nM | 4.49 |
| CHEMBL1172325 | — | IC50 | = | 34690.0 | nM | 4.46 |
| CHEMBL1170203 | — | IC50 | = | 38000.0 | nM | 4.42 |
| CHEMBL1172323 | — | IC50 | = | 39820.0 | nM | 4.40 |
| CHEMBL1170815 | — | IC50 | = | 40290.0 | nM | 4.39 |
| CHEMBL1172326 | — | IC50 | = | 43480.0 | nM | 4.36 |
| CHEMBL1170388 | — | IC50 | = | 44100.0 | nM | 4.36 |
| CHEMBL1172542 | — | IC50 | = | 45000.0 | nM | 4.35 |
| CHEMBL1170112 | — | IC50 | = | 49190.0 | nM | 4.31 |
| CHEMBL1169918 | — | IC50 | = | 51500.0 | nM | 4.29 |
| CHEMBL1169732 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL1171394 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL1171395 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL1172360 | — | IC50 | = | 168000.0 | nM | - |
| CHEMBL1170202 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL1170019 | — | IC50 | = | 135000.0 | nM | - |
| CHEMBL1169914 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL1172543 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL1172359 | — | IC50 | = | 107000.0 | nM | - |
| CHEMBL1172358 | — | IC50 | = | 143000.0 | nM | - |
| CHEMBL1172124 | — | IC50 | = | 103000.0 | nM | - |
| CHEMBL1171937 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL1172702 | — | IC50 | = | 207000.0 | nM | - |
| CHEMBL1172701 | — | IC50 | = | 104000.0 | nM | - |
| CHEMBL1171517 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL1172499 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL1170021 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL1170020 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL1170007 | — | IC50 | = | 236000.0 | nM | - |