Assay Detail
Binding
CHEMBL1175694
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human CDK7/Cyclin H/MAT1
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Cyclin-dependent kinase 7/ cyclin H (CHEMBL2111288) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Activity of substituted thiophene sulfonamides against malarial and mammalian cyclin dependent protein kinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.04 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1171969 | — | — | 1 | 6.70 |
| CHEMBL1172129 | — | — | 1 | 6.40 |
| CHEMBL1170012 | — | — | 1 | 6.40 |
| CHEMBL1172329 | — | — | 1 | 6.16 |
| CHEMBL1171972 | — | — | 1 | 6.10 |
| CHEMBL1171238 | — | — | 1 | 4.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1171969 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL1172129 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL1170012 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL1172329 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL1171972 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL1171238 | — | IC50 | = | 33400.0 | nM | 4.48 |