Assay Detail
Binding
CHEMBL1175697
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human CDK2/Cyclin A
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Cyclin-dependent kinase 2/cyclin A (CHEMBL2094128) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Activity of substituted thiophene sulfonamides against malarial and mammalian cyclin dependent protein kinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 4.81 | 5.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1171969 | — | — | 1 | 5.00 |
| CHEMBL1172129 | — | — | 1 | 4.98 |
| CHEMBL1172329 | — | — | 1 | 4.94 |
| CHEMBL1170012 | — | — | 1 | 4.90 |
| CHEMBL1171238 | — | — | 1 | 4.54 |
| CHEMBL1171972 | — | — | 1 | 4.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1171969 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL1172129 | — | IC50 | = | 10500.0 | nM | 4.98 |
| CHEMBL1172329 | — | IC50 | = | 11500.0 | nM | 4.94 |
| CHEMBL1170012 | — | IC50 | = | 12500.0 | nM | 4.90 |
| CHEMBL1171238 | — | IC50 | = | 28500.0 | nM | 4.54 |
| CHEMBL1171972 | — | IC50 | = | 31400.0 | nM | 4.50 |