Assay Detail
Functional
CHEMBL1175698
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Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 assessed as inhibition of [3H]hypoxanthine incorporation after 24 hrs by microtiter plate scintillation counting
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Activity of substituted thiophene sulfonamides against malarial and mammalian cyclin dependent protein kinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.11 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL416956 | MEFLOQUINE | 4.0 | 1 | 7.00 |
| CHEMBL1276127 | INDIRUBIN | 2.0 | 1 | 5.96 |
| CHEMBL50894 | ALSTERPAULLONE | — | 1 | 5.37 |
| CHEMBL1172129 | — | — | 1 | 4.77 |
| CHEMBL1172329 | — | — | 1 | 4.67 |
| CHEMBL1171238 | — | — | 1 | 4.63 |
| CHEMBL1171969 | — | — | 1 | 4.61 |
| CHEMBL1171972 | — | — | 1 | 4.51 |
| CHEMBL1170012 | — | — | 1 | 4.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL416956 | MEFLOQUINE | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL1276127 | INDIRUBIN | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL50894 | ALSTERPAULLONE | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL1172129 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL1172329 | — | IC50 | = | 21200.0 | nM | 4.67 |
| CHEMBL1171238 | — | IC50 | = | 23300.0 | nM | 4.63 |
| CHEMBL1171969 | — | IC50 | = | 24700.0 | nM | 4.61 |
| CHEMBL1171972 | — | IC50 | = | 31000.0 | nM | 4.51 |
| CHEMBL1170012 | — | IC50 | = | 31700.0 | nM | 4.50 |