Assay Detail
Functional
CHEMBL1175729
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at delta opioid receptor in mouse vas deferens assessed as inhibition of electrically-stimulated muscle contraction
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Tissue | Vas deferens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design and synthesis of trivalent ligands targeting opioid, cholecystokinin, and melanocortin receptors for the treatment of pain.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 6.83 | 7.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1172253 | — | — | 1 | 7.96 |
| CHEMBL1172251 | — | — | 1 | 7.40 |
| CHEMBL1172252 | — | — | 1 | 7.22 |
| CHEMBL1172428 | — | — | 1 | 6.96 |
| CHEMBL235743 | — | — | 1 | 6.92 |
| CHEMBL1172249 | — | — | 1 | 6.89 |
| CHEMBL1172245 | — | — | 1 | 6.62 |
| CHEMBL1172429 | — | — | 1 | 6.43 |
| CHEMBL1172247 | — | — | 1 | 6.39 |
| CHEMBL1172248 | — | — | 1 | 6.21 |
| CHEMBL1172244 | — | — | 1 | 6.14 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1172253 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL1172251 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL1172252 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL1172428 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL235743 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL1172249 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL1172245 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL1172429 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL1172247 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL1172248 | — | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL1172244 | — | IC50 | = | 730.0 | nM | 6.14 |