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Assay Detail

CHEMBL1175846

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human MCF-7TN-R cells assessed as reduction in cell viability after 24 hrs by MTT assay
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Confidence 1 — Organism
Curated By Autocuration

Publication

Novel anti-viability ceramide analogs: design, synthesis, and structure-activity relationship studies of substituted (S)-2-(benzylideneamino)-3-hydroxy-N-tetradecylpropanamides.
Liu J, Antoon JW, Ponnapakkam A, Beckman BS, Foroozesh M.
Bioorg Med Chem (2010) 18 : 5316 -5322
PubMed 20639111 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 21 4.59 5.12

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL560401 1 5.12
CHEMBL444463 1 5.07
CHEMBL1169885 1 4.99
CHEMBL1169887 1 4.90
CHEMBL1169715 1 4.72
CHEMBL1169723 1 4.71
CHEMBL1172594 1 4.66
CHEMBL1171285 1 4.62
CHEMBL1171284 1 4.56
CHEMBL1169886 1 4.55
CHEMBL1169716 1 4.53
CHEMBL1171431 1 4.50
CHEMBL1169714 1 4.49
CHEMBL1169717 1 4.36
CHEMBL1170089 1 4.12
CHEMBL1171089 1 4.08
CHEMBL1171090 1 4.06
CHEMBL1171245 1 -
CHEMBL1171088 1 -
CHEMBL1169897 1 -
CHEMBL1171087 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL560401 IC50 = 7670.0 nM 5.12
CHEMBL444463 IC50 = 8590.0 nM 5.07
CHEMBL1169885 IC50 = 10260.0 nM 4.99
CHEMBL1169887 IC50 = 12500.0 nM 4.90
CHEMBL1169715 IC50 = 18970.0 nM 4.72
CHEMBL1169723 IC50 = 19330.0 nM 4.71
CHEMBL1172594 IC50 = 21710.0 nM 4.66
CHEMBL1171285 IC50 = 24100.0 nM 4.62
CHEMBL1171284 IC50 = 27480.0 nM 4.56
CHEMBL1169886 IC50 = 28130.0 nM 4.55
CHEMBL1169716 IC50 = 29350.0 nM 4.53
CHEMBL1171431 IC50 = 31250.0 nM 4.50
CHEMBL1169714 IC50 = 32630.0 nM 4.49
CHEMBL1169717 IC50 = 43690.0 nM 4.36
CHEMBL1170089 IC50 = 75290.0 nM 4.12
CHEMBL1171089 IC50 = 82940.0 nM 4.08
CHEMBL1171090 IC50 = 87710.0 nM 4.06
CHEMBL1171245 IC50 = 101500.0 nM -
CHEMBL1171088 IC50 = 103900.0 nM -
CHEMBL1169897 IC50 = 100400.0 nM -
CHEMBL1171087 IC50 = 216500.0 nM -