Assay Detail
Binding
CHEMBL1176015
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to Mycobacterium tuberculosis purine nucleoside phosphorylase by spectrophotometric analysis
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mycobacterium tuberculosis |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Purine nucleoside phosphorylase (CHEMBL1169594) ↗| Type | SINGLE PROTEIN |
| Organism | Mycobacterium tuberculosis |
Publication
Crystallographic and docking studies of purine nucleoside phosphorylase from Mycobacterium tuberculosis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 8 | 4.68 | 4.90 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL388931 | — | — | 1 | 4.90 |
| CHEMBL184 | ACYCLOVIR | 4.0 | 1 | 4.90 |
| CHEMBL182 | GANCICLOVIR | 4.0 | 1 | 4.80 |
| CHEMBL1425 | MERCAPTOPURINE ANHYDROUS | 4.0 | 1 | 4.10 |
| CHEMBL1467 | ALLOPURINOL | 4.0 | 1 | - |
| CHEMBL266540 | QUINAZOLINONE | — | 1 | - |
| CHEMBL859 | OXYPURINOL | 2.0 | 1 | - |
| CHEMBL1172777 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL388931 | — | Kd | = | 12589.25 | nM | 4.90 |
| CHEMBL184 | ACYCLOVIR | Kd | = | 12589.25 | nM | 4.90 |
| CHEMBL182 | GANCICLOVIR | Kd | = | 15848.93 | nM | 4.80 |
| CHEMBL1425 | MERCAPTOPURINE ANHYDROUS | Kd | = | 79432.82 | nM | 4.10 |
| CHEMBL1467 | ALLOPURINOL | Kd | = | 1000000.0 | nM | - |
| CHEMBL266540 | QUINAZOLINONE | Kd | = | 316227.77 | nM | - |
| CHEMBL859 | OXYPURINOL | Kd | = | 794328.23 | nM | - |
| CHEMBL1172777 | — | Kd | = | 316227.77 | nM | - |